Association between cervical vertebral maturation stages and dental calcification stages in patients with unilateral complete cleft lip and palate

doi:10.7518/hxkq.2019.02.010

Abstract

Abstract:

Objective The purpose of the study is to investigate the relationship between dental calcification stages (DCS) and cervical vertebral maturation stages (CVMS) in patients with unilateral complete cleft lips and palates (UCLP) and to provide a theoretical basis for the treatment time selection of cleft lip and palate (CLP) patients. Methods A total of 123 UCLP patients and 215 non-CLP subjects were selected. The DCS of the left mandibular canine, premolar, and second molar in non-CLP subjects and on both cleft sides of UCLP patients were assessed utilizing the Demirjian method. CVMS was observed utilizing the Baccetti method. The results were analyzed by Spearman rank correlation, and the correlation coefficients were compared. Results There was a correlation between the CVMS and the DCS of the left mandibular canine, the first premolar, the second premolar, and the second molar in the non-CLP subjects and on both cleft sides of the UCLP patients (r=0.762-0.864, P<0.05; r=0.809-0.914, P<0.05, respectively). The correlation between the CVMS and the DCS of the mandibular first premolar was highest among the UCLP patients. Except for the first and the second premolars of UCLP females, the correlation between the DCS and the CVMS of the other teeth did not differ among the non-CLP subjects (P>0.05). Conclusion DCS can be utilized as a biological index to determine the growth development statuses. The correlation between the CVMS and the DCS of the mandibular first premolar was the highest.

Key words: unilateral complete cleft lip and palate, dental calcification stages, cervical vertebral maturation stages

CLC Number:

R783.5

Xiaoxu Fang,Cunhui Fan,Qing Xue,Tao Xu,Wenlin Xiao,Zhonghui Tian,Xiaolin Xu. Association between cervical vertebral maturation stages and dental calcification stages in patients with unilateral complete cleft lip and palate[J]. West China Journal of Stomatology, 2019, 37(2): 180-186.

Figures/Tables 6

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References 28

[1]	Tanaka SA, Mahabir RC, Jupiter DC , et al. Updating the epidemiology of cleft lip with or without cleft palate[J]. Plast Reconstr Surg, 2012,129(3):511e-518e. doi: 10.1097/PRS.0b013e3182402dd1 URL
[2]	Camacho-Basallo P, Yáñez-Vico RM, Solano-Reina E , et al. Five radiographic methods for assessing skeletal maturity in a Spanish population: is there a correlation[J]. Acta Odontol Scand, 2017,75(2):106-112. doi: 10.1080/00016357.2016.1265145 URL
[3]	DuPlessis EA, Araujo EA, Behrents RG , et al. Relationship between body mass and dental and skeletal development in children and adolescents[J]. Am J Orthod Dentofacial Orthop, 2016,150(2):268-273. doi: 10.1016/j.ajodo.2015.12.031 URL
[4]	Srkoc T, Mestrović S, Anić-Milosević S , et al. Association between dental and skeletal maturation stages in croatian subjects[J]. Acta Clin Croat, 2015,54(4):445-452.
[5]	Valizadeh S, Eil N, Ehsani S , et al. Correlation between dental and cervical vertebral maturation in Iranian females[J]. Iran J Radiol, 2012,10(1):1-7. doi: 10.5812/iranjradiol URL
[6]	Demirjian A, Goldstein H, Tanner JM . A new system of dental age assessment[J]. Human Biol, 1973,45(2):211-227.
[7]	Demirjian A, Goldstein H . New systems for dental maturity based on seven and four teeth[J]. Ann Hum Biol, 1976,3(5):411-421. doi: 10.1080/03014467600001671 URL
[8]	Baccetti T, Franchi L , McNamara JA Jr . An improved version of the cervical vertebral maturation (CVM) method for the assessment of mandibular growth[J]. Angle Orthod, 2002,72(4):316-323.
[9]	Baccetti T, Franchi L , McNamara Jr JA . The cervical vertebral maturation (CVM) method for the assessment of optimal treatment timing in dentofacial orthopedics[J]. Seminars Orthod, 2005,11(3):119-129. doi: 10.1053/j.sodo.2005.04.005 URL
[10]	范存晖, 薛青 . 儿童青少年牙龄与颈椎骨龄相关性研究[C]. 南昌: 第十四次全国口腔正畸学术会议论文集, 2015: 340-341.
	Fan CH, Xue Q . Correlation between tooth age and cervical vertebra age in children and adolescents[C]. Nanchang: Proceedings of the 14th National Conference on Orthodontics, 2015: 340-341.
[11]	张舒, 王璟, 谭英 , 等. 成都地区儿童和青少年牙龄与颈椎骨龄的相关性分析[J]. 华西口腔医学杂志, 2012,30(6):620-623. doi: 10.3969/j.issn.1000-1182.2012.06.014
	Zhang S, Wang J, Tan Y , et al. Relationships between dental calcification stages and cervical vertebral bone ages among children and adolescents in Chengdu[J]. West Chin J Stomatol, 2012,30(6):620-623. doi: 10.3969/j.issn.1000-1182.2012.06.014
[12]	Sachan K, Sharma VP, Tandon P . A correlative study of dental age and skeletal maturation[J]. Indian J Dent Res, 2011,22(6):882. doi: 10.4103/0970-9290.94698 URL
[13]	Chen J, Hu H, Guo J , et al. Correlation between dental maturity and cervical vertebral maturity[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010,110(6):777-783. doi: 10.1016/j.tripleo.2010.08.006 URL
[14]	Baccetti T, Reyes BC , McNamara JA Jr . Craniofacial changes in Class Ⅲ malocclusion as related to skeletal and dental maturation[J]. Am J Orthod Dentofacial Orthop, 2007, 132(2): 171.e1-171.e12.
[15]	申勇, 范存晖, 杨茜 , 等. 单侧完全性唇腭裂男性患者的牙齿发育状况[J]. 山东大学学报(医学版), 2014,52(7):99-101. doi: 10.6040/j.issn.1671-7554.1.2014.002
	Shen Y, Fan CH, Yang Q , et al. Dental development of male patients with complete unilateral cleft lip and palate[J]. J Shandong Univ (Health Sci), 2014,52(7):99-101. doi: 10.6040/j.issn.1671-7554.1.2014.002
[16]	李巍然, 林久祥, 傅民魁 . 唇腭裂术后反颌患者的咀嚼肌肌电图研究[J]. 口腔正畸学, 1995,2(1):4-6.
	Li WR, Lin JX, Fu MK . Study on the electromyography of masticatory muscles in crossbitepatients with cleft lip and palate after operation[J]. Chin J Orthod, 1995,2(1):4-6.
[17]	Sun L, Li WR . Cervical vertebral maturation of children with orofacial clefts[J]. Cleft Palate Craniofac J, 2012,49(6):683-688. doi: 10.1597/11-006 URL
[18]	Sun L, Li WR . Cervical vertebral maturation of female children with orofacial clefts[J]. Cleft Palate Craniofac J, 2013,50(5):535-541. doi: 10.1597/11-215 URL
[19]	Hazza’a AM, Rawashdeh MA, Al-Jamal G , et al. Dental development in children with cleft lip and palate: a comparison between unilateral and bilateral clefts[J]. Eur J Paediatr Dent, 2009,10(2):90-94. doi: 10.1007/BF03321607 URL
[20]	Bailit HL . Dental development in children with cleft palates[J]. J Dent Res, 1968,47(4):664. doi: 10.1177/00220345680470042601 URL
[21]	Ranta R . Comparison of tooth formation in noncleft and cleft-affected children with and without hypodontia[J]. ASDC J Dent Child, 1982,49(3):197-199.
[22]	Harris EF, Hullings JG . Delayed dental development in children with isolated cleft lip and palate[J]. Arch Oral Biol, 1990,35(6):469-473. doi: 10.1016/0003-9969(90)90210-2 URL
[23]	Haring FN . Dental development in cleft and noncleft subjects[J]. Angle Orthod, 1976,46(1):47-50.
[24]	Ranta R . A review of tooth formation in children with cleft lip/palate[J]. Am J Orthod Dentofacial Orthop, 1986,90(1):11-18. doi: 10.1016/0889-5406(86)90022-3 URL
[25]	Pham AN, Seow WK, Shusterman S . Developmental dental changes in isolated cleft lip and palate[J]. Pediatr Dent, 1997,19(2):109-113.
[26]	Chongcharueyskul P, Wangsrimonkol T, Pisek P , et al. Correlations between cervical vertebral maturation (CVM) and dental development in Thai cleft patients[J]. J Med Assoc Thai, 2015,98(Suppl 7):S92-S100.
[27]	Olze A, Schmeling A, Taniguchi M , et al. Forensic age estimation in living subjects: the ethnic factor in wisdom tooth mineralization[J]. Int J Legal Med, 2004,118(3):170-173. doi: 10.1007/s00414-004-0434-7 URL
[28]	Borzabadi-Farahani A, Lane CJ, Yen SL . Late maxillary protraction in patients with unilateral cleft lip and palate: a retrospective study[J]. Cleft Palate Craniofac J, 2014,51(1):e1-e10.

CVMS分期	DCS分期	尖牙		第一前磨牙		第二前磨牙		第二磨牙
CVMS分期	DCS分期	男	女	男	女	男	女	男	女
CS1	C	0	0	0	0	0	0	18.2	10
	D	9.1	20	9.1	30	18.2	30	54.5	40
	E	54.5	50	81.8	70	81.8	70	27.3	50
	F	36.4	30	9.1	0	0	0	0	0
	G	0	0	0	0	0	0	0	0
	H	0	0	0	0	0	0	0	0
CS2	C	0	0	0	0	0	0	0	10
	D	0	0	6.7	20	20	30	46.7	40
	E	53.3	30	53.3	60	53.3	70	26.7	50
	F	40	70	40	20	20	0	20	0
	G	6.7	0	0	0	6.7	0	6.7	0
	H	0	0	0	0	0	0	0	0
CS3	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	30	6.3	0
	E	12.5	30	18.8	28.6	25	70	37.5	0
	F	62.5	70	50	57.1	50	0	31.3	42.9
	G	18.8	0	18.8	14.3	18.8	0	25	57.1
	H	6.3	0	12.5	0	6.2	0	0	0
CS4	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	0	0	0
	E	0	30	0	0	0	0	16.7	0
	F	41.7	70	41.7	57.1	58.3	57.1	41.7	42.9
	G	33.3	0	25	14.3	25	14.3	41.7	57.1
	H	25	0	33.3	28.6	16.7	28.6	0	0
CS5	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	0	0	0
	E	0	0	0	0	0	0	0	0
	F	0	0	0	0	12.5	0	37.5	0
	G	37.5	20	25	40	25	40	62.5	60
	H	62.5	80	75	60	62.5	60	0	40
CS6	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	0	0	0
	E	0	0	0	0	0	0	0	0
	F	0	0	0	0	0	0	0	0
	G	0	20	0	0	0	0	22.2	12.5
	H	100	80	100	100	100	100	77.8	87.5

CVMS分期	DCS分期	尖牙		第一前磨牙		第二前磨牙		第二磨牙
CVMS分期	DCS分期	男	女	男	女	男	女	男	女
CS1	C	0	0	0	0	0	0	18.2	30
	D	9.1	30	18.2	40	27.3	40	54.5	30
	E	81.8	60	81.8	60	72.7	60	27.3	40
	F	9.1	10	0	0	0	0	0	0
	G	0	0	0	0	0	0	0	0
	H	0	0	0	0	0	0	0	0
CS2	C	0	0	0	0	0	0	0	10
	D	0	20	18.2	30	20	30	46.7	40
	E	53.3	60	81.8	70	66.7	70	26.7	50
	F	40	20	0	0	6.7	0	26.7	0
	G	6.7	0	0	0	6.7	0	0	0
	H	0	0	0	0	0	0	0	0
CS3	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	20	0	12.5	14.3
	E	53.3	28.6	43.8	37.5	66.7	37.5	37.5	28.6
	F	40	57.1	43.8	62.5	6.7	62.5	31.3	28.6
	G	6.7	14.3	6.3	0	6.7	0	18.8	28.6
	H	0	0	6.3	0	0	0	0	0
CS4	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	0	0	0
	E	8.3	0	0	0	16.7	0	25	0
	F	33.3	21.4	50	71.4	58.3	71.4	50	57.1
	G	41.7	64.3	33.3	14.3	16.7	14.3	25	42.9
	H	16.7	14.3	16.7	14.3	8.3	14.3	0	0
CS5	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	0	0	0
	E	0	0	0	0	0	0	0	0
	F	0	0	50	20	12.5	20	25	0
	G	25	20	33.3	20	25	20	75	60
	H	75	80	16.7	60	62.5	60	0	40
CS6	C	0	0	0	0	0	0	0	0
	D	0	0	0	0	0	0	0	0
	E	0	0	0	0	0	0	0	0
	F	0	0	0	0	0	0	0	0
	G	0	0	0	0	0	0	33.3	12.5
	H	100	100	100	100	100	100	66.7	87.5

性别	牙位	r_N	r_NC	Z值	P值
男	尖牙	0.852*	0.816*	0.756 7	>0.05
	第一前磨牙	0.788*	0.846*	1.120 9	>0.05
	第二前磨牙	0.812*	0.839*	0.541 5	>0.05
	第二磨牙	0.864*	0.809*	1.178 3	>0.05
女	尖牙	0.786*	0.877*	1.756 8	>0.05
	第一前磨牙	0.762*	0.905*	2.900 8	<0.01
	第二前磨牙	0.781*	0.901*	2.501 1	<0.05
	第二磨牙	0.815*	0.889*	1.603 4	>0.05

性别	牙位	r_N	r_C	Z值	P值
男	尖牙	0.852*	0.830*	0.459 4	>0.05
	第一前磨牙	0.788*	0.861*	1.473 4	>0.05
	第二前磨牙	0.812*	0.843*	0.628 6	>0.05
	第二磨牙	0.864*	0.817*	1.027 8	>0.05
女	尖牙	0.786*	0.875*	1.706 8	>0.05
	第一前磨牙	0.762*	0.914*	3.204 2	<0.01
	第二前磨牙	0.781*	0.907*	2.692 3	<0.01
	第二磨牙	0.815*	0.898*	1.863 4	>0.05