Research progress on the relationship between triggering receptor expressed on myeloid cells 1 and 2 and malignant tumors

doi:10.7518/hxkq.2017.06.016

Abstract

Abstract:

Increasing scientific evidence supports the positive relationship between inflammation and cancer development. The immune response initiated by pattern recognition receptors is critical to triggering of tumor-associated inflammation. Triggering receptor expressed on myeloid cells (TREM) is an immunoglobulin of the super transmembrane glycoprotein family, which is mainly expressed on select groups of myeloid cells. The most important members of TREM comprise TREM-1 and TREM-2. Activation of TREM-1 and TREM-2 signaling is initiated upon binding of their ligands. Subsequently, cross-linking reactions of downstream effectors occur, resulting in inflammation regulation. Recently, the connection between TREM and malignant tumors has been widely noticed and studied. This review summarizes studies of association between TREM-1, TREM-2, and malignant tumors in the medical field to provide new ideas for study on the correlation between periodontitis and oral cavity cancer.

Key words: triggering receptor expressed on myeloid cells 1, triggering receptor expressed on myeloid cells 2, chronic inflammation, malignant tumour

CLC Number:

R730.2

Yun Yang, Wuchao Wu, Yafei Wu, Lei. Zhao. Research progress on the relationship between triggering receptor expressed on myeloid cells 1 and 2 and malignant tumors[J]. West China Journal of Stomatology, 2017, 35(6): 648-653.

References 38

[1]	Coussens LM, Werb Z.Inflammation and cancer[J]. Nature, 2002, 420(6917):860-867.
[2]	Mantovani A.Cancer: inflammation by remote control[J]. Nature, 2005, 435(7043):752-753.
[3]	Correale C, Genua M, Vetrano S, et al.Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response[J]. Gastroenterology, 2013, 144(2):346-356.
[4]	Solinas G, Germano G, Mantovani A, et al.Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation[J]. J Leukoc Biol, 2009, 86(5):1065-1073.
[5]	Ho CC, Liao WY, Wang CY, et al.TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer[J]. Am J Respir Crit Care Med, 2008, 177(7):763-770.
[6]	Sigalov AB.A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopoly-saccharide-induced septic shock[J]. Int Immunopharmacol, 2014, 21(1):208-219.
[7]	Karapanagiotou EM, Pelekanou E, Charpidou A, et al.Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: a prognostic marker for lung metastases from solid malignancies[J]. Anticancer Res, 2008, 28(2B):1411-1415.
[8]	Yao Y, Li H, Chen J, et al.TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 depen-dent manner in lung cancer[J]. Oncotarget, 2016, 7(20):29620-29634.
[9]	Wu J, Li J, Salcedo R, et al.The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma[J]. Cancer Res, 2012, 72(16):3977-3986.
[10]	Liao R, Sun TW, Yi Y, et al.Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma[J]. Cancer Sci, 2012, 103(6):984-992.
[11]	Duan M, Wang ZC, Wang XY, et al.TREM-1, an inflam-matory modulator, is expressed in hepatocellular carcinoma cells and significantly promotes tumor progression[J]. Ann Surg Oncol, 2015, 22(9):3121-3129.
[12]	Schenk M, Bouchon A, Seibold F, et al.TREM-1-expressing intestinal macrophages crucially amplify chronic inflamma-tion in experimental colitis and inflammatory bowel diseases[J]. J Clin Invest, 2007, 117(10):3097-3106.
[13]	Zhou J, Chai F, Lu G, et al.TREM-1 inhibition attenuates inflammation and tumor within the colon[J]. Int Immuno-pharmacol, 2013, 17(2):155-161.
[14]	Kim SK, Kim SY, Kim JH, et al.A nineteen gene-based risk score classifier predicts prognosis of colorectal cancer patients[J]. Mol Oncol, 2014, 8(8):1653-1666.
[15]	Genua M, Monico MC, D’Alessio S, et al. DOP008 the ab-sence of the triggering receptor expressed on myeloid cells type-2 (TREM-2) induces a transmissible and protective intestinal microbiota for colitis and colitis associated can-cer[J]. J Crohn Colitis, 2014, 8:S18.
[16]	Genua M, Monico MC, D'Alessio S, et al. 149 intestinal microbiota defined by the absence of the triggering receptor expressed on myeloid cells type-2 (TREM-2) is transmissible and protects from colitis associated cancer[J]. Gastroentero-logy, 2014, 146(5):S42.
[17]	Vasaturo A, Verweij D, Heinzerling L, et al.Immune in-filtrates impact on the prediction of prognosis and response to immunotherapy of melanoma patients[J]. J Transl Med, 2015, 13(S1):12.
[18]	Nguyen AH, Koenck C, Quirk SK, et al.Triggering recep-tor expressed on myeloid cells in cutaneous melanoma[J]. Clin Transl Sci, 2015, 8(5):441-444.
[19]	Kim EJ, Choi MR, Park H, et al.Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary car-cinoma cells and mortality in obesity-resistant BALB/c mice[J]. Breast Cancer Res, 2011, 13(4):1-13.
[20]	Roberto A, Fabiola G, Alejandro B, et al.Expression of TREM-1 in patients with invasive cervical cancer and pre-cursor lesions[J]. Rev Med Inst Mex Seguro Soc, 2015, 53(6):722-727.
[21]	Li H, Li W, Yi X, et al.Differential expression of TREM-1 in myelogenous leukemia cells[J]. Blood, 2013, 122(21):4951.
[22]	Tessarz AS, Cerwenka A.The TREM-1/DAP12 pathway[J]. Immunol Lett, 2008, 116(2):111-116.
[23]	Bouchon A, Dietrich J, Colonna M.Cutting edge: inflamma-tory responses can be triggered by TREM-1, a novel recep-tor expressed on neutrophils and monocytes[J]. J Immunol, 2000, 164(10):4991-4995.
[24]	Hara H, Ishihara C, Takeuchi A, et al.The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors[J]. Nat Immunol, 2007, 8(6):619-629.
[25]	Yao L, Jermanus C, Barbetta B, et al.Porphyromonas gin-givalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells[J]. Mol Oral Microbiol, 2010, 25(2):89-101.
[26]	Volná P, Lebduska P, Dráberová L, et al.Negative regula-tion of mast cell signaling and function by the adaptor LAB/NTAL[J]. J Exp Med, 2004, 200(8):1001-1013.
[27]	Schneider T, Hoffmann H, Dienemann H, et al.Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3[J]. J Thorac Oncol, 2011, 6(7):1162-1168.
[28]	Hamerman JA, Jarjoura JR, Humphrey MB, et al.Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12[J]. J Immunol, 2006, 177(4):2051-2055.
[29]	Ito H, Hamerman JA.TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells[J]. Eur J Immunol, 2012, 42(1):176-185.
[30]	Perrot I, Blanchard D, Freymond N, et al.Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage[J]. J Immunol, 2007, 178(5):2763-2769.
[31]	Javed F, Warnakulasuriya S.Is there a relationship between periodontal disease and oral cancer? A systematic review of currently available evidence[J]. Crit Rev Oncol Hematol, 2016, 97:197-205.
[32]	Chen SS, Wang K, Zhao J, et al.Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva[J]. J Periodont Res, 2017, 52(3):512-521.
[33]	Bostanci N, Thurnheer T, Belibasakis GN.Involvement of the TREM-1/DAP12 pathway in the innate immune responses to Porphyromonas gingivalis[J]. Mol Immunol, 2011, 49(1/2):387-394.
[34]	Bostanci N, Thurnheer T, Aduse-Opoku J, et al.Porphyro-monas gingivalis regulates TREM-1 in human polymorpho-nuclear neutrophils via its gingipains[J]. PLoS ONE, 2013, 8(10):e75784.
[35]	Ha NH, Park DG, Woo BH, et al.Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs[J]. Cytokine, 2016, 86:64-72.
[36]	Gholizadeh P, Eslami H, Yousefi M, et al.Role of oral mi-crobiome on oral cancers, a review[J]. Biomed Pharmaco-ther, 2016, 84:552-558.
[37]	Groeger S, Jarzina F, Mamat U, et al.Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gin-givalis on human oral epithelial cells: B7-H1 induction by Porphyromonas gingivalis fractions[J]. Immunobiology, 2017, 222(2):137-147.
[38]	Zhang SS, Tang J, Yu SY, et al.Expression levels of B7-H3 and TLT-2 in human oral squamous cell carcinoma[J]. Oncol Lett, 2015, 10(2):1063-1068.