Abstract:

Objective To study the link of Helicobacter pylori salive test cassette（HPS） and 13C-urea breath test （13C-UBT） on detecting Helicobacter pylori infection of stomach, and the sensitivity as well as specificity should be determined. Methods A screening trial of 13C-UBT and HPS tests was carried out 130 patients included 106 positive and 24 negative results of 13C-UBT. As gold standards of 13C-UBT, a comparison study with HPS was evaluated using Bayes formula. Results The sensitivity, specificity, accuracy, positive and negative predictive value of HPS was 68.87%, 58.33%, 66.92%, 87.95%, 29.79% respectively. The coincidence was 66.92%. Conclusion There is a correlation between results of 13C-UBT and HPS. Combination of 13C-UBT and HPS may compensate the blind zone of 13C-UBT
in detecting oral Helicobacter pylori infection. 13C-UBT could not be used as a gold standard to judge the validation of HPS in detecting Helicobacter pylori oral infection. The methods can be used at the same time in clinic.

Key words: Helicobacter pylori； specificity； sensitivity； 13C-urea breath test； Helicobacter pylori salive test , cassette