Abstract:

Objective　The aim of this studywas to investigate the mechanism(MDR) ofmultidrug resistance(MDR) ofmucoe- pidermoid carcinoma in salivary gland.Methods　40 cases of mucoepidermoid carcinoma in salivary gland were examined the MDR gene product P-glycoprotein using a monoclonal antibody JSB-1. And 10 of themwere also investigated by detecting the ex- pression of GST-π. All the cases had not been accepted any therapy before the samples were collected.Results　①Positive ex- pression of JSB-1 was observed in 27 of the 40 specimens. The positive expressionwas related not onlywith clinical stage, but also with differentiation degree.②The GST-πpositive expressionwas found in 9 of 10 cases. Therewas no significant different between the positive expression of JSB-1 and GST-π.Conclusion　JSB-1 and GST-πplay an important role in MDR of mucoepidermoid carcinoma.

Key words: multidrug resistance, P-glycoprotein, glutathione, mucoepidermoid carcinoma