Objective This study aims to analyze the long-term stability of the anterior teeth and hard tissue of skeletal class Ⅲ malocclusion after a three-year orthodontic surgery by systematic review. Methods All studies about skeletal classⅢ malocclusion with orthodontic-surgery were searched by computer-based retrieval and manual retrieval; the deadline is December 2013. The literature, filtered according to the inclusion criteria and exclusion criteria, was performed with quality assessment. The same indicators of the anterior location and hard tissue stability were combined and evaluated with metaanalysis and descriptive analysis by Rev Man5.2. Results Four before-and-after comparison study articles with 180 cases were included. The grades of the four literature evaluation were A. The meta-analysis results showed that comparing the threeyear post-orthodontic-surgery and post-orthodontic-surgery, the total weighted mean difference (WMD) of U1-SN was 4.29 (P<0.05); the WMD of L1-MP, OB, OJ, SNA, SNB, ANB, and MP-SN were-1.58, 0,-0.41,-0.58, 0.25,-0.70, and 0.39, respectively (P>0.05). The measurement methods of A and B point position were different, hence the qualitative description were as follows: point A remained at a relatively stable position, and point B had some replacement compared with postoperative (P<0.05). Conclusion To the skeletal class Ⅲ malocclusion after three-year orthodontic-surgery, the position of the lower anterior teeth could be kept stable, as well as the overbite and the overjet of the anterior teeth; only the upper incisor has a lip-inclined relapse. The maxillary could also be kept stable, and the mandibular had a little relapse.