Abstract:

Objective:Porphyromonas gingivalis (Pg) is one of the main putative pathogens of periodontal disease, especially of adult periodontitis. This in vitro study was aimed at observing the inhibitory activities of 7 commonly used antimicrobical drugs on 106 stains of Pg which isolated from subgingival plaques of siteswith adult periodontits.Methods:Kirby-Bauer paper diskmethodwas used in this study.Results:Pgwas highly susceptible to Clindamycin, Sulfamzthoxazole timethoprin, Tetracycline and Cefazolin, the susceptibility rates were 93.4%, 78.3%, 60.4% and 56.6% respectively.Conclusion:Majority of the strains of Pg was moderately susceptible to cefalexin and acetylspiramycin, while no strains of Pgwas susceptible to PenicillinG. The concentrations of Pg solutions (105CFU/ml, 106CFU/ml and 108CFU/ml) had notinfluence on the results. This data is helpful for clinically an- tibiotic selection of periodontal treatment.

Key words: porphyromonas gingivalis, antimicrobial drug, drug susceptibility test