West China Journal of Stomatology ›› 2021, Vol. 39 ›› Issue (1): 88-93.doi: 10.7518/hxkq.2021.01.013

Previous Articles     Next Articles

Research progress on two-component signal transduction systems in Porphyromonas gingivalis

Yao Ke(), Cai Jingyi, Zhao Lei, Wu Yafei, Zhao Zhihe, Shen Daonan()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China
  • Received:2019-05-31 Revised:2020-10-08 Online:2021-02-01 Published:2021-03-02
  • Contact: Shen Daonan E-mail:1577885360@qq.com;shendaonan@126.com
  • Supported by:
    The National Natural Science Foundation of China(81771077);Science and Technology Department of Sichuan Province(2018SZ0161)

Abstract:

Porphyromonas gingivalis (P. gingivalis), a Gram-negative oral anaerobe, is considered to be a major pathogenic agent involved in the onset and progression of chronic periodontitis. P. gingivalis must be able to perceive and respond to the complicated changes in host to survive the environmental challenges, in which the two-component signal transduction systems (TCSs) play critical roles by connecting input signals to cellular physiological output. Canonical TCS consists of a sensor histidine kinase and a cognate response regulator that functions via a phosphorylation cascade. In this review, the roles of TCSs in P. gingivalis were demonstrated by illustrating the target genes and modulation modes, which may help elucidate the underlying mechanisms in future studies.

Key words: Porphyromonas gingivalis, two-component signal transduction systems, gene regulation

CLC Number: