West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (3): 319-324.doi: 10.7518/hxkq.2018.03.017

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Pharmacokinetics and drug safety of oral infectious disease during pregnancy

Hongyu Li(), Yachuan Zhou, Xue-dong Zhou, Liwei Zheng()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-08-13 Revised:2017-12-29 Online:2018-06-01 Published:2018-06-01
  • Supported by:
    The National Natural Science Foundation of China (81470711);National Key Clinical Specialist Construction Program of National Health and Family Planning Commission of China, Pediatric Dentistry (0040305401313).

Abstract:

Pregnancy is a time of particular vulnerability in terms of physiologic changes resulting in higher risk of oral infectious diseases. There is emerging evidence showing that irrational dental treatment and drug therapy are associated with adverse pregnancy outcomes, including infant malformation or spontaneous abortion. This article reviews the pharmacokinetics of medications in pregnant women and the fetus and introduces a guideline for drug therapy and common dental drugs used during pregnancy.

Key words: pregnancy, oral health, pharmacokinetics, medication

CLC Number: