West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (3): 291-295.doi: 10.7518/hxkq.2018.03.012

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In vivo study of 3D printed porous tantalum implant on osseointegration

Kexin Su(), Ping Ji, Han Wang, Linlin Li, Leizhen Su, Chao Wang()   

  1. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China
  • Received:2017-10-15 Revised:2018-01-12 Online:2018-06-01 Published:2018-06-01
  • Supported by:
    National Natural Science Foundation for Young Scholars of China (11402042);Project of Basic and Frontier Research Plan of Chongqing (CSTC2015jcyjA10027);Social and People’s Livelihood Project of Science and Technology Commission of Chongqing (CSTC2015shmszx10008);Project of Health and Family Plan Commission of Chongqing (2017-MSXMD73);Program for Innovation Team Building at Institutions of Higher Education in Chongqing in 2016 (CXTDG2016-02006).

Abstract:

Objective This work aims to investigate the effect of porous tantalum and porous titanium on osseointegration. Methods Two kinds of porous materials with same microporous parameters, namely, porous tantalum and porous titanium, were fabricated by computer-aided design (CAD) modeling and 3D printing technology. A defect model was established in 24 New Zealand white rabbits in the bilateral femoral lateral malleolus at the left and right side of each animal. Then, animals were randomly divided into two groups, and bone defects were repaired by porous tantalum and porous titanium (experimental and control groups, respectively). Animals were sacrificed at two, four, and eight weeks after implantation. Gross observation and methylene blue-acid fuchsin staining were used to observe osseointegration of the implant and bone interface, and the osseointegration strength of implant bone interface was tested by push-out test. Results At two, four, and eight weeks after operation, the new bone tissue in the two groups increased gradually, and new bone trabecula appeared and grew into the pores of the materials. No significant difference (P>0.05) in osteo-genesis and the strength of implant bone tissue interface between the two groups was observed. Conclusion 3D printed porous tantalum implants, which exhibit comparable osseointegration capabilities to porous titanium implants, can form an early biological combination with bone tissue.

Key words: porous tantalum, 3D printing, osseoin-tegration, implant repair

CLC Number: