West China Journal of Stomatology

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Expression of Proliferating Cell Nuclear Antigen、bcl-2 in Gray Gingival Tissue

CHENLin1, ZHUGuo-wei1, YANGXiao- hong1, LIUHua-qing2   

  1. 1.Dept. ofProsthodontics, StomatologicalHospital ofZunyi Medical College;2.Dept. ofPathology, Zunyi Medical College, Zunyi563003,China
  • Received:2004-06-25 Revised:2004-06-25 Online:2004-06-20 Published:2004-06-20

Abstract:

Objective To studythe expression of PCNA、bcl-2 protein in gray and normal gingival tissue, and to investigate the biological effect of procelain-fused-to-metals(PFM).Methods Gray gingival tissue animal model was established by PFM pros- thesis and immunohistochemistry S-P method was used to detect the PCNA、bcl-2 protein expression in gingival tissue after 3 months, 6 months in PFM groups and control group.Results The expression of PCNAhad significant difference between the 3th month group and the control group(P<0.05)|no significant difference was found between the 6th month group and the control group(P>0.05). The expression of bcl-2 had no significant difference between the 6th month group and the control group(P> 0.05).Conclusion There were a correlation between the expression of PCNA and inflammation of the gray gingival tissue;The expression of PCNA and bcl-2 protein does not indicate that gray gingival tissue had dysplasia change.

Key words: proliferating cell nuclear antigen, bcl-2, immunohistochemistry, porcelain-fused-to-metals crown, discol- oration