West China Journal of Stomatology

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Preparation of Lymphatic Targeting Dosage Form: Pingyangmycin Absorbed on Activated Carbon Nanoparticles

Ming-lei1,WEN Yu-ming2, WANG Chang-mei2, LILong-jiang2, WANGXiao-yi2   

  1. 1.Dept. ofStomatology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou450052,China;2.Dept. ofOral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu610041,China
  • Received:2004-06-25 Revised:2004-06-25 Online:2004-06-20 Published:2004-06-20


Objective To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.Meth- ods The activated carbon nanoparticles(CH-NP) were prepared for drug carrier. Pingyangmycin(PYM), a high sensitive anti- cancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYMwas absorbed on activated carbon enough, resulting in a newformulation of PYM (PYM-CH-NP). The absorbency of PYMon activated carbon nanoparticles was evaluated.Results The diameter distribu- tion for CH-NP ranged form 136 nmto 540 nm, the average diameterwas 176 nm.The proportion of CH-NPto PYMwas increased and more absorbency of PYMon activated carbon nanoparticleswas achieved.Conclusion The activated carbon nanoparticles has high absorbency of PYM. The newformulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.

Key words: pingyangmycin, activated carbon, nanoparticle, oral cancer, lymph metastasis