West China Journal of Stomatology

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Expression of MMP-2 and MMP-3 in Periodontal Tissues of Rat Periodontitis Model

ZHAO Xiao-qin1, MENG Shu1, WU Ya-fei2, CHEN Yu3, GE Song1   

  1. 1. Key. Laboratory of Oral Biomedical Engineering Ministry of  Education, Sichuan University, Chengdu 610041, China; 2. Dept. of Periodontology, West China College of Stomatology, Sichuan University, Chengdu 610041, China; 3. Dept. of Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2006-06-25 Revised:2006-06-25 Online:2006-06-20 Published:2006-06-20

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Abstract:

Objective To investigate the expression of MMP-2 and MMP-3 in periodontal tissues of rat peri-odontitis model at different stages of inflammation of varied severity. Methods The periodontal tissues were im-munohistochemically stained by antibody of MMP-2 and MMP-3. Results MMP-2 and MMP-3 were both strongly positive in gingival epithelia and fibroblasts in periodontal ligament in rat periodontitis model. And chronic periodon-titis showed lower expression of MMP-2 and MMP-3 than that of acute gingivitis and acute peridontitis. Conclusion The expression of MMP-2 and MMP-3 varies in different stage of periodontitis. MMP-2 and MMP-3 may play an important role in development of periodontitis.

Key words:  matrix metalloproteinases, periodontitis, immunohistochemistry, animal model

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