Abstract:

Objective　To explore the combined effects of orthodontic force and inflammation on the remodelling of periodontal tissues.Methods　The upper firstmolars underwentmesial orthodontic force on 48 rats suffering experimental periodontitis and 48 rats injected lipopolysaccharide, respectively.Results　TheTNF-αprotein expression in the compressed periodontal tissues fluctu- ated during 0,2,12 hours and 2,7,14 days stages, the OD value got to the peak in the compressed periodontal tissues in 2 days. Conclusion　The mechanical remodelling effectswere hindered due tothe circumstance of acute or chronic inflammation. The re- search suggests that the orthodontic treatment to adult patients with periodontal inflammation should be taken carefully.

Key words: periodontal inflammation, orthodontic force, remodelling, tumor necrosis factorα