Abstract:

Objective　To investigate the effect of the treatment of periapical diseaseswith recombinant human bone morphoge- netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application.Methods　The endotoxin- bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical disease models were built. The rhBMP-2 composite was mixed by rhBMP-2,TCP,collagen and metronidazole and used in the treatment of periapi- cal diseases in dogmodels as root apex screen. The imageology and pathology researchwere went on.Results　The effective rate of the experimental group was remarkably higherthan that of the carrier group and the control groupwith remarkable statistical dif- ference(P<0.05). The quality of the repair of tissue was obviously better than the two other groups.Conclusion　The rhBMP- 2 composite is a promising biological root-canal filling material.

Key words: recombinant human bone morphogenetic protein, periapical disease, root canal therapy