Abstract:

Objective　In order to determine the influence of bFGF on the biological characteristics of osteoblasts and periodon- tal ligament cells, the author investigate the influence of bFGF on the migration, proliferation of osteoblasts and periodontal liga- ment fibroblasts between osteoblasts and fibroblasts.Methods　The forth generation of osteoblasts and periodontal ligament fibro- blast were obtained and the woundingmodelin vitroof themwas founded. The cellswere cultured in mediumswith orwithout bF- GF. Their migration and proliferation were observed and measured.Results　Osteoblasts migrated faster than fibroblasts in com- mon culture mediumwithout bFGF and the periodontal ligament fibroblasts in culture mediumwith bFGF had higher migration rate than other groups. bFGF promoted the proliferation of both two kinds of cells.Conclusion　bFGF could accelerate periodontal fi- broblasts′proliferation and migration.

Key words: periodontal ligament fibroblasts, osteoblasts, basic fibroblast growth factors