Recombinant Human Bone Morphogenetic Ptrotem-2 Transform NIBT3 FSbroblast to Osteo-like Cells

West China Journal of Stomatology

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Recombinant Human Bone Morphogenetic Ptrotem-2 Transform NIBT3 FSbroblast to Osteo-like Cells

WANG Junlin,LIU Yuan，Jin yan，WANG Xingwen, Li Yuan

Dept.of Oral Histology and Pathology, The Fourth Military Medical Ummsay, Xi'an 710032, China

Received:2004-10-25 Revised:2004-10-25 Online:2004-10-20 Published:2004-10-20

Abstract

Abstract:

Objective To examine the effect of recombinant human bone morphogenetic protein-2(rhBMP-2) on NIH3T3 cells. Methods The NII-UT3 cells~cultured in DMEM with 50 ug/L rhBMP-2. the proliferation ability, alkaline phos- phatase (ALP) activity and osteocalcin (0C) quantity of NIH3T3 cells were investigated. Results The cells showed decreased proliferation ability but enhanced ALP activity and OC quantity. Conclusion 50 1rg/L rhBMP-2 can transform NIH373 fibroblasts to osteo-like cells.

Key words: fibroblast, bone morphogenetic proteins, osteoblast

WANG Junlin,LIU Yuan，Jin yan，WANG Xingwen, Li Yuan. Recombinant Human Bone Morphogenetic Ptrotem-2 Transform NIBT3 FSbroblast to Osteo-like Cells[J]. West China Journal of Stomatology.

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Recombinant Human Bone Morphogenetic Ptrotem-2 Transform NIBT3 FSbroblast to Osteo-like Cells

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