Abstract:

Objective To study the effect of growth hormone (GH) on the proliferation and type II collagen secretion of chon- drocytes of mandibular condyle in rabbit in vitro .Methods Flow cytometry(FCM) and immunohistochemical technique were employed to observe the possible changes. Results 1TThe exogenic GH can enhance the proliferation and synthesis of DNA of the chondrocytes of mandibular condyle in rabbit in vitro.The suitable concentration of GH is 10 pg/ml厂[be synthesis of DNA reach- es the highest level after 12 hours, while the proliferation index (PI) hits the highest after 24 hours.② GH(10 J-g/ml) can stimu- late the secretion of type 1) collagen of the chondrocytes. Conclusion The exogenic GH can enhance the proliferation, the syn- thesis of DNA and the secretion of type n collagen of the chondrocytes of mandibular condyle in rabbit in vitro

Key words: growth hormone, chondrocytes of mandibular condyle, proliferation, type II collagen