Abstract:

Objective　The expression ofKi-67 antigen of ameloblastomawas exmanied in orderto investigate the different proliferation activity of histological variants of ameloblastoma and its clinical significance.Methods　70 cases of different histolog- ical specimen of ameloblastoma were analyzed by immunohistochemical method using Ki-67 antibody. The Label Indexwas calcu- lated in percentage of Ki-67 positive cells after examinedwith an image analysis system.Results　The results showed that the La- beled Index in malignant ameloblastoma was the highest 14·72%±2·87%. The Labeled Index in solid ameloblastoma was in the middle, among which the follicular 4·42%±1·05% was higher than the plexiform 3·64%±1·23%. The Labeled Index in mono-cystic ameloblastoma was the lowest 2·21%±1·09%.Conclusion　The results demonstrated that the proliferation activity varied according to the histological pattern of ameloblastoma. The prognosis with different proliferation activitywas also varied ac- cordingly.

Key words: ameloblastoma, Ki-67 antigen, immunohistochemistry