Abstract:

Objective　The purpose of this study was to investigate the cisplatin release in peripheral blood and tumor tissue after cisplatin-loaded albumin microspheres (CDDP-AMS) were infused through lingual artery for treating carcinoma of tongue.Methods 　Anticancer agent cisplatin was encapsulated with biodegradable and non-antigenic albumin. The cisplatin-loaded albumin microsph- eres, which were 56·3μm in diameter, were used for treating 7 patients with squamous carcinoma of tongue by infusing through lingual artery. The cisplatin in peripheral venous blood and carcinoma tissue were measured for analyzing the drug releasein vivo.Results　 Concentration of the drug in peripheral venous blood increased to the highest level in 90 minutes after CDDP-AMS was infused through lingual arterial and still could be detected until 10th day. The cisplatin concentration in tumor tissue kept considerably stable and could be detected until 17 days.Conclusion　CDDP-AMS had the effect of controlled releaseinvive. Effective and steady local drug concen- tration played the role of killing tumor cells, the low concentration in peripheral blood reduced the side effects of cisplatin tominimum as well. It is concluded that CDDP-AMS is a useful and recommendable method for treating the carcinoma of tongue.

Key words: cisplatin-loaded albumin microsphere, carcinoma of tongue, controlled release, treatment