Abstract:

Objective　To investigate the expression change of integrinα5during mandibular fracture healing.Methods　 Using rabbit mandibular fracture model, the fractured bone tissues were obtained and paraffin slices were made on the days of 1, 3,5,7,14,30,60 and 90 after surgery, respectively. Non-fractured mandibles were used as normal control. LsAB immunohisto- chemical methodwas used to detectthe expression of integrinα5in bone tissue, especially on osteoblasts and osteoclasts.Results　 Integrinα5was widely expressed in fractured bone and surrounding soft tissues. The expression of integrinα5increased 7 days after fracture, peaked in 14 to 30 days and returned to nearly normal in 60-90 days.Conclusion　During mandibular fracture healing, the expression of integrinα5in bone tissue increased clearly. It is estimated that integrinα5playes an important role in fracture healing.

Key words: integrinα5, mandible, fracture healing, immunohistochemistry