The Expression of Basic Fibroblast Growth Factors and Their Receptors in Human Dental Pulps

Abstract

Abstract:

Objective:The aim of this study was to observe the expression and the effect of basic fibroblast growth factors (bFGFs) and their receptors (bFGFRs) in human dental pulps.Methods:By collecting sound human third molars and premolars, the paraffin sample of tooth slice were prepared with ordinary methods. The bFGFs and bFGFRof human dental pulpswere examined by using SABC immunohistochemical technique.Results:Strong specific staining for bFGF was observed in the odontoblasts of healthy te- eth, and positive stainingwas found in other pulp cells and vascular endothelial cells. The faint signal of bFGFRwas detected only in the odontoblasts, and negative in other pulp cells.Conclusion:The expression of basic fibroblast growth factor (bFGF) and its receptor (bFGFR) in human dental pulp suggests that bFGF and its receptormay play an important role in the reactionary and re- pairable dentinnogenesis.

Key words: basic fibroblast growth factor, receptor, dental pulp

Zhang Ying, WangMeixia, Zhang Yu, et al. The Expression of Basic Fibroblast Growth Factors and Their Receptors in Human Dental Pulps[J]. West China Journal of Stomatology.

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The Expression of Basic Fibroblast Growth Factors and Their Receptors in Human Dental Pulps

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