Abstract:

Objective:The objective of this study is to compare effects of formocresol, camphorated phenol and Ya Kan (metronedazole) on endotoxin levels in canals of chronic periapical periodontitis.Methods:Atotal of 30 patientswith chronic periacal periodontitis were selected from outpatients, and 10 cases eachwere randomly picked out to treat by sealingwith formoresol, camphorated phe- nol and Ya Kan respectively. All patientswere both sampled before and after sealing of these disinfectants, and chromogenic sub- strate method of limulus amebocyte lysate (LAL) testwas used to measure levels of endotoxin.Results:The effects of Ya Kan, formocresol and camphorated phenol on levels of endotoxin did not showed significant difference.Conclusion:Some anti-anaerobic bacterial drugs can be used to treat chronic periapical periodontitis.

Key words: chronic periapical periodontitis, endotoxin, metronedazole