Radiofrequency thermocoagulation combined with doxorubicin injection for treatment of trigeminal neuralgia mandibular branch

doi:10.7518/hxkq.2022.04.012

Abstract

Abstract:

Objective This study aimed to evaluate the clinical application value of 3D printed template-guided radiofrequency thermocoagulation combined with doxorubicin injection for the treatment of trigeminal neuralgia mandibular branch. Methods A total of 50 patients with primary trigeminal neuralgia mandibular branch in the hospital from January 2019 to September 2020 were randomly divided into two groups: 3D printed template-guided radiofrequency thermocoagulation combined with doxorubicin injection was used as the research group (n=25), and 3D printed template guided radiofrequency thermocoagulation was used as the control group (n=25). Comparative analysis of visual analogue score (VAS) was conducted before and immediately after surgery and at 1, 3, 6, and 12 months after surgery. The Brisman efficacy evaluation criteria for trigeminal neuralgia was used to evaluate the therapeutic effect of each postoperative follow-up period, and postoperative complications were observed. Results The VAS immediately after surgery and at 1, 3, 6, and 12 months after surgery in the two groups was significantly lower than that before surgery, with statistical significance (P<0.05). According to Brisman efficacy evaluation criteria for trigeminal neuralgia, no significant difference was found in the efficacy between the two groups at 1 and 3 months after surgery (P>0.05). At 6 and 12 months postoperatively, the effectiveness of the research group was higher than that of the control group, and the differences were statistically significant (P<0.05). In the research group, no recurrence occurred during the follow-up period, whereas in the control group, one, two, and four recurrences occurred 3, 6, and 12 months after surgery, respectively. No obvious complications were found in both groups. Conclusion 3D printed template-guided radiofrequency thermocoagulation combined with doxorubicin injection for the treatment of trigeminal neuralgia mandibular branch could enhance the long-term curative effect and reduce the recurrence rate, thus worthy of clinical promotion and application.

Key words: 3D printed template, radiofrequency thermocoagulation, doxorubicin, trigeminal neuralgia, mandibular branch

CLC Number:

R 782

Zhang Lingge, Li Jie, Li Jihong, Tang Hongchao, Liu Yuxue. Radiofrequency thermocoagulation combined with doxorubicin injection for treatment of trigeminal neuralgia mandibular branch[J]. West China Journal of Stomatology, 2022, 40(4): 446-450.

Figures/Tables 4

Fig 1

Tab 1

Tab 2

Comparison of VAS among different follow-up period in the two groups

组别	术前	术后即刻	术后1个月	术后3个月	术后6个月	术后12个月
研究组	8.17±0.72	2.60±0.91 $*$	2.87±1.25 $*$	2.40±0.91*	2.20±0.86 $*$	2.07±0.70 $*$
对照组	8.25±0.87	3.07±0.96*	3.27±1.22 $*$	3.00±1.00 $*$	2.73±0.96 $*$	2.47±0.83 $*$

Tab 2

Tab 3

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组别	男/女（n）	年龄	病程	术前VAS
研究组	9/16	60.30±6.53	6.66±4.17	8.17±0.72
对照组	8/17	62.60±9.40	6.83±4.47	8.25±0.87
	0.089	0.552	0.097	0.318
P值	0.765	0.595	0.925	0.758

组别	术后1个月				术后3个月				术后6个月				术后12个月
组别	治愈	显效	有效	无效	治愈	显效	有效	无效	治愈	显效	有效	无效	治愈	显效	有效	无效
研究组	24	1	0	0	23	0	2	0	23	2	0	0	24	1	0	0
对照组	22	1	2	0	20	1	3	1	19	0	4	2	17	1	3	4

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