West China Journal of Stomatology ›› 2022, Vol. 40 ›› Issue (3): 335-340.doi: 10.7518/hxkq.2022.03.014

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The prognostic value of preoperative peripheral blood inflammatory indicators for squamous cell carcinoma of tongue

Qin Shuo1(), Li Chunmei2, Li Ran1, Hu Shuang2, Li Guanghui1, Sun Minglei1()   

  1. 1.Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    2.Dept. of Stomatology, Zhengzhou People's Hospital, Zhengzhou 450052, China
  • Received:2021-09-04 Revised:2022-04-08 Online:2022-06-01 Published:2022-06-01
  • Contact: Sun Minglei E-mail:15621581731@163.com;mlsun@zzu.edu.cn
  • Supported by:
    Henan Provincial Medical Science and Technology Research Plan Provincial and Ministerial Joint Construction Project(SBGJ202002067);Key Scientific Research Projects of Colleges and Universities in Henan Province(22A320015);Correspondence: Sun Minglei, E-mail: mlsun@zzu.edu.cn

Abstract: Objective

A study was conducted to investigate the value of preoperative peripheral blood inflammatory indicators in the prediction of tongue squamous cell carcinoma (TSCC) prognosis.

Methods

This retrospective analysis included 210 patients who underwent radical resection for TSCC in the Department of Oral and Maxillofacial Surgery of The First Affiliated Hospital of Zhengzhou University from January 2010 to December 2017. Receiver operating characteristic curve was conducted to determine the best cut-off values of platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR). The Kaplan-Meier method and Log-rank test were conducted for univariate analysis, and the Cox proportional hazard regression model was conducted for multivariate analysis. A Nomogram model was established based on the independent risk factors, which were screened by Cox regression model.

Results

The univariate analysis showed that PLR, NLR, tumor differentiation, and T, N, and TNM stages were TSCC’s prognostic factors (P<0.05). Multivariate analysis showed that PLR and N and TNM stages were TSCC's independent risk factors (P<0.05). The C-index of the Nomogram was 0.701 (95%CI: 0.651-0.752). The calibration curve shows that the predicted survival rate of the nomogram was in good agreement with the relative survival rate.

Conclusion

Preoperative peripheral blood inflammatory indicators can potentially be used to predict TSCC prognosis.

Key words: peripheral blood inflammatory indicators, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, tongue squamous cell carcinoma, prognosis, Nomogram model

CLC Number: