Roles of autophagy onself-renewal and differentiation of mesenchymal stem cells

doi:10.7518/hxkq.2020.06.017

Abstract

Abstract:

Mesenchymal stem cells (MSCs), which have the potential of self-replication and differentiation, are a very valuable cell source for stem cell-based medical therapy. Their application has opened up a new way for disease research. Although MSCs can maintain cell stemness through self-renewal, with the prolongation of cell passage and culture time, the stemness of MSCs gradually decays, and the cell aging and differentiation potential decreases gradually. Autophagy is a highly conserved cytological process that degrades the modified, excess, and deleterious cytoplasmic components in autophagosomes, which are then degraded by fusion with lysosomes. As the main intracellular degradation and recycling pathway, autophagy plays an active role in maintaining cell homeostasis, self-renewal and pluripotency. In this paper, the role of autophagy in self-renewal and maintenance of multidirectional differentiation potential of MSCs was reviewed, which laid a theoretical foundation and practical basis for the research and application of MSCs.

Key words: autophagy, mesenchymal stem cell, differentiation, self-renewal

CLC Number:

Q254

Liu Xinchen, Lu Jinjin, Chen Yumeng, Qiu Ying, Zheng Mengdan, Wang Zilin, Li Xiangwei. Roles of autophagy onself-renewal and differentiation of mesenchymal stem cells[J]. West China Journal of Stomatology, 2020, 38(6): 704-707.

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