Research progress on the expression and function of erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins in oral-related diseases

doi:10.7518/hxkq.2020.02.018

Abstract

Abstract:

Erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins (Eph/ephrin) can participate in the regulation of growth and development and promote the development of diseases through short-distance signal transduction between cells. To study the mechanism of Eph/ephrin and oral-related diseases, we provided a new theoretical basis and a strategy for the treatment of oral diseases. The Eph/ephrin pathway has been used to regulate oral diseases, especially in periodontal disease prevention, orthodontic bone reconstruction, and biological treatment of oral tumors. This paper reviews the research progress of Eph/ephrin pathway in oral-related diseases.

Key words: erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins, periodontitis, orthodontics, tumor

CLC Number:

Wang Qi, Liu Yan, Zhao Yun, Sun Lizhong, Wang Linxuan, Han Mei, Mi Fanglin. Research progress on the expression and function of erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins in oral-related diseases[J]. West China Journal of Stomatology, 2020, 38(2): 218-223.

References 45

[1]	Matsuo K, Otaki N . Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseases[J]. Cell Adh Migr, 2012,6(2):148-156.
[2]	吴梓齐, 杨涛源, 王景云 . 浅谈EphrinB2/ephB4在骨重建中的作用[J]. 中华老年口腔医学杂志, 2014,12(3):184-187.
	Wu ZQ, Yang TY, Wang JY . The role of EphrinB2/ephB4 in bone reconstruction[J]. Chin J Geriatric Dent, 2014,12(3):184-187.
[3]	赵鹃, 毛英杰, 谷志远 . 骨吸收与骨形成耦联中Eph/ephrin信号转导的研究进展[J]. 生物化学与生物物理进展, 2009,36(9):1101-1105.
	Zhao J, Mao YJ, Gu ZY . Progress in researches of Eph/ephrin signaling in coupling of bone resorption and bone formation[J]. Prog Bioche Biophy, 2009,36(9):1101-1105.
[4]	Ji YJ, Hwang YS, Mood K , et al. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1[J]. Nat Commun, 2014(5):3516.
[5]	Arvanitis DN, Béhar A, Tryoen-Tóth P , et al. Ephrin B1 maintains apical adhesion of neural progenitors[J]. Development, 2013,140(10):2082-2092.
[6]	Rakic P . Specification of cerebral cortical areas[J]. Science, 1988,241(4862):170-176.
[7]	Bouché E, Romero-Ortega MI, Henkemeyer M , et al. Reelin induces EphB activation[J]. Cell Res, 2013,23(4):473-490.
[8]	Dimidschstein J, Passante L, Dufour A , et al. Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration[J]. Neuron, 2013,79(6):1123-1135.
[9]	García-Frigola C, Carreres MI, Vegar C , et al. Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms[J]. Development, 2008,135(10):1833-1841.
[10]	Adams RH, Wilkinson GA, Weiss C , et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis[J]. Genes Dev, 1999,13(3):295-306.
[11]	Wang HU, Chen ZF, Anderson DJ . Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4[J]. Cell, 1998,93(5):741-753.
[12]	Lindskog H, Kim YH, Jelin EB , et al. Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals[J]. Development, 2014,141(5):1120-1128.
[13]	Nakayama M, Nakayama A, van Lessen M , et al. Spatial regulation of VEGF receptor endocytosis in angiogenesis[J]. Nat Cell Biol, 2013,15(3):249-260.
[14]	Sawamiphak S, Seidel S, Essmann CL , et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis[J]. Nature, 2010,465(7297):487-491.
[15]	Liao C, Cheng T, Wang S , et al. Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathways[J]. Bone, 2017,101:10-20.
[16]	Xie H, Cui Z, Wang L , et al. PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis[J]. Nat Med, 2014,20(11):1270-1278.
[17]	Zhao C, Irie N, Takada Y , et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis[J]. Cell Metab, 2006,4(2):111-121.
[18]	Matsuo K, Irie N . Osteoclast-osteoblast communication[J]. Arch Biochem Biophys, 2008,473(2):201-209.
[19]	Tonna S, Takyar FM, Vrahnas C , et al. EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis[J]. FASEB J, 2014,28(10):4482-4496.
[20]	Irie N, Takada Y, Watanabe Y , et al. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis[J]. J Biol Chem, 2009,284(21):14637-14644.
[21]	Sun W, Zhao C, Li Y , et al. Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity[J]. Cell Discov, 2016,2:16015.
[22]	Kwan Tat S, Pelletier JP, Amiable N , et al. Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes[J]. Arthritis Res Ther, 2009,11(4):R119.
[23]	Li M, Zhang C, Jin L , et al. Porphyromonas gingivalis lipopolysaccharide regulates ephrin/Eph signalling in human periodontal ligament fibroblasts[J]. J Periodontal Res, 2017,52(5):913-921.
[24]	张祎 . 牙龈卟啉单胞菌脂多糖对成骨细胞—破骨细胞间EphB4-ephrinB2双向传导信号的影响[D]. 长春: 吉林大学, 2013.
	Zhang Y . Effects of lipopolysaccharides from Porphyromonas gingivalis on bidirectional EphB4-ephrinB2 signaling in osteoblasts-osteoclasts[D]. Changchun: Jilin University, 2013.
[25]	Gao A, Wang X, Yu H , et al. Effect of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on the expression of EphA2 in osteoblasts and osteoclasts[J]. In Vitro Cell Dev Biol Anim, 2016,52(2):228-234.
[26]	雷利红, 黄玫, 吴燕岷 , 等. EphrinB2/EphB4在牙槽骨吸收-重建过程中的作用[J]. 第三军医大学学报, 2013,35(21):2331-2335.
	Lei HL, Huang M, Wu YM , et al. Role of EphrinB2/EphB4 during alveolar bone resorption and remodeling[J]. J Third Milit Med Univ, 2013,35(21):2331-2335.
[27]	Martin TJ, Allan EH, Ho PW , et al. Communication between ephrinB2 and EphB4 within the osteoblast lineage[J]. Adv Exp Med Biol, 2010,658:51-60.
[28]	Pozniak PD, White MK, Khalili K . TNF-α/NF-κB signaling in the CNS: possible connection to EPHB2[J]. J Neuroimmune Pharmacol, 2014,9(2):133-141.
[29]	Wang L, Zhang J, Wang C , et al. Low concentrations of TNF-α promote osteogenic differentiation via activation of the ephrinB2-EphB4 signalling pathway[J]. Cell Prolif, 2017,50(1). doi: 10.1111/cpr.12311.
[30]	Einhorn TA . The cell and molecular biology of fracture healing[J]. Clin Orthop Relat Res, 1998,355(Suppl):S7-S21.
[31]	Shen LL, Zhang LX, Wang LM , et al. Disturbed expression of EphB4, but not EphrinB2, inhibited bone regeneration in an in vivo inflammatory microenvironment[J]. Mediators Inflamm, 2016: 6430407.
[32]	Bletsa A, Berggreen E, Brudvik P . Interleukin-1alpha and tumor necrosis factor-alpha expression during the early phases of orthodontic tooth movement in rats[J]. Eur J Oral Sci, 2006,114(5):423-429.
[33]	AlSwafeeri H, ElKenany W, Mowafy M , et al. Crevicular alkaline phosphatase activity during the application of two patterns of orthodontic forces[J]. J Orthod, 2015,42(1):5-13.
[34]	Ghijselings E, Coucke W, Verdonck A , et al. Long-term changes in microbiology and clinical periodontal variables after completion of fixed orthodontic appliances[J]. Orthod Craniofac Res, 2014,17(1):49-59.
[35]	Sen S, Diercke K, Zingler S , et al. Compression induces Ephrin-A2 in PDL fibroblasts via c-fos[J]. J Dent Res, 2015,94(3):464-472.
[36]	Diercke K, Kohl A, Lux CJ , et al. Strain-dependent up-regulation of ephrin-B2 protein in periodontal ligament fibroblasts contributes to osteogenesis during tooth movement[J]. J Biol Chem, 2011,286(43):37651-37664.
[37]	Diercke K, Sen S, Kohl A , et al. Compression-dependent up-regulation of ephrin-A2 in PDL fibroblasts attenuates osteogenesis[J]. J Dent Res, 2011,90(9):1108-1115.
[38]	杜沿林, 张辉, 孟蕾 , 等. 大鼠正畸牙移动过程中ephrinA2在牙周膜内的表达与分布[J]. 牙体牙髓牙周病学杂志, 2016,26(2):74-77, 120.
	Du YL, Zhang H, Meng L , et al. EphrinA2 expression and distribution in periodontal ligament during orthodontic tooth movement in rats[J]. Chin J Conserv Dent, 2016,26(2):74-77, 120.
[39]	Ayman O, Shilpa B, Kellen H , et al. Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors[J]. Mol Carcinog, 2017,56(3):1189-1196.
[40]	Nakada M, Anderson EM, Demuth T , et al. The phosphorylation of ephrin-B2 ligand promotes glioma cell migrationand invasion[J]. Int J Cancer, 2010,126(5):1155-1165.
[41]	Shao Z, Zhang WF, Chen XM , et al. Expression of EphA2 and VEGF in squamous cell carcinoma of the tongue: correlation with the angiogenesis and clinical outcome[J]. Oral Oncol, 2008,44(12):1110-1117.
[42]	Noguti J, De Moura CF, De Jesus GP , et al. Metastasis from oral cancer: an overview[J]. Cancer Genomics Proteomics, 2012,9(5):329-335.
[43]	Eri S, Ayumi T, Riki T , et al. Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma[J]. PLoS One, 2017,12(11):e0188965.
[44]	Ferguson BD, Tretiakova MS, Lingen MW , et al. Expression of the EPHB4 receptor tyrosine kinase in head and neck and renal malignancies—implications for solid tumors and potential for therapeutic inhibition[J]. Growth Factors, 2014,32(6):202-206.
[45]	Rutkowski R, Mertens-Walker I, Lisle JE , et al. Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand[J]. Int J Cancer, 2012,131(5):E614-E624.