Relationship among areca nut, intracellular reactive oxygen species, and autophagy

doi:10.7518/hxkq.2020.01.014

Abstract

Abstract:

The relationship between areca nut as a primary carcinogen and oral cancer has been widely concerned. Areca can change the levels of reactive oxygen species (ROS) and autophagy in cells, and the levels of ROS and autophagy are closely related to the occurrence and development of tumors. This paper reviewed the relationships among areca nut, intracellular ROS, and autophagy.

Key words: areca nut, reactive oxygen species, autophagy, oral submucous fibrosis, oral cavity cancer

CLC Number:

R739.8

Xu Zhi,Lü Fengyuan,Jiang Erhui,Zhao Xiaoping,Shang Zhengjun. Relationship among areca nut, intracellular reactive oxygen species, and autophagy[J]. West China Journal of Stomatology, 2020, 38(1): 80-85.

References 59

[1]	Warnakulasuriya S . Global epidemiology of oral and oropharyngeal cancer[J]. Oral Oncol, 2009,45(4/5):309-316.
[2]	Zhang XL, Reichart PA . A review of betel quid chewing, oral cancer and precancer in Mainland China[J]. Oral Oncol, 2007,43(5):424-430.
[3]	高义军, 彭海艳, 尹晓敏 , 等. 湖南省娄底市城区中小学生嚼槟榔情况调查[J]. 中华口腔医学杂志, 2009,44(11):686-689.
	Gao YJ, Peng HY, Yin XM , et al. Epidemiological study of betel nut chewing among elementary and middle school students in Loudi city, Hunan Province[J]. Chin J Stomatol, 2009,44(11):686-689.
[4]	Petti S . Lifestyle risk factors for oral cancer[J]. Oral Oncol, 2009,45(4/5):340-350.
[5]	张春江, 吕飞杰, 陶海腾 . 槟榔活性成分及其功能作用的研究进展[J]. 中国食物与营养, 2008(6):50-53.
	Zhang CJ, Lü FJ, Tao HT . Advances in studies on active ingredients and their functions of areca nut[J]. Food Nutrit China, 2008(6):50-53.
[6]	牟肖男, 杨文强, 王文婧 , 等. 槟榔的化学成分[J]. 暨南大学学报(自然科学与医学版), 2014,35(1):56-60.
	Mu XN, Yang WQ, Wang WJ , et al. Chemical constituents from the fruits of Areca catechu[J]. J Jinan Univ (Nat Sci Med Ed), 2014,35(1):56-60.
[7]	郭峰, 翦新春, 周晌辉 , 等. 口腔黏膜下纤维性变癌变的病理及临床生物学行为回顾性研究[J]. 中华口腔医学杂志, 2011,46(8):494-497.
	Guo F, Jian XC, Zhou SH , et al. A retrospective study of oral squamous cell carcinomas originated from oral submucous fibrosis[J]. Chin J Stomatol, 2011,46(8):494-497.
[8]	Li L, Tan J, Miao Y , et al. ROS and autophagy: interactions and molecular regulatory mechanisms[J]. Cell Mol Neurobiol, 2015,35(5):615-621.
[9]	Rahal A, Kumar A, Singh V , et al. Oxidative stress, prooxidants, and antioxidants: the interplay[J]. Biomed Res Int, 2014,2014:761264.
[10]	Mizushima N, Levine B, Cuervo AM , et al. Autophagy fights disease through cellular self-digestion[J]. Nature, 2008,451(7182):1069-1075.
[11]	Cecconi F, Levine B . The role of autophagy in mammalian development: cell makeover rather than cell death[J]. Dev Cell, 2008,15(3):344-357.
[12]	Dewaele M, Maes H, Agostinis P . ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy[J]. Autophagy, 2010,6(7):838-854.
[13]	Cook JA, Gius D, Wink DA , et al. Oxidative stress, redox, and the tumor microenvironment[J]. Semin Radiat Oncol, 2004,14(3):259-266.
[14]	Esposito F, Ammendola R, Faraonio R , et al. Redox control of signal transduction, gene expression and cellular senescence[J]. Neurochem Res, 2004,29(3):617-628.
[15]	Reczek CR, Chandel NS . ROS-dependent signal transduction[J]. Curr Opin Cell Biol, 2015,33:8-13.
[16]	Balaban RS, Nemoto S, Finkel T . Mitochondria, oxidants, and aging[J]. Cell, 2005,120(4):483-495.
[17]	Goetz ME, Luch A . Reactive species: a cell damaging rout assisting to chemical carcinogens[J]. Cancer Lett, 2008,266(1):73-83.
[18]	Wu WS . The signaling mechanism of ROS in tumor progression[J]. Cancer Metastasis Rev, 2006,25(4):695-705.
[19]	Hayes JD , McMahon M. The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer[J]. Mol Cell, 2006,21(6):732-734.
[20]	Nioi P, Nguyen T . A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity[J]. Biochem Biophys Res Commun, 2007,362(4):816-821.
[21]	Ohta T, Iijima K, Miyamoto M , et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth[J]. Cancer Res, 2008,68(5):1303-1309.
[22]	Lin WJ, Jiang RS, Wu SH , et al. Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study[J]. J Oncol, 2011,2011:525976.
[23]	Chen CL, Chi CW, Liu TY . Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo[J]. J Toxicol Environ Health A, 2002,65(3/4):327-336.
[24]	Diakowska D, Lewandowski A, Kopeć W , et al. Oxidative DNA damage and total antioxidant status in serum of patients with esophageal squamous cell carcinoma[J]. Hepatogastroenterology, 2007,54(78):1701-1704.
[25]	Tanaka H, Fujita N, Sugimoto R , et al. Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C[J]. Br J Cancer, 2008,98(3):580-586.
[26]	Lin MH, Liu SY, Liu YC . Autophagy induction by a natural ingredient of areca nut[J]. Autophagy, 2008,4(7):967-968.
[27]	Lin MH, Hsieh WF, Chiang WF , et al. Autophagy induction by the 30-100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species[J]. Oral Oncol, 2010,46(11):822-828.
[28]	Thangjam GS, Kondaiah P . Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes[J]. J Periodont Res, 2009,44(5):673-682.
[29]	Illeperuma RP, Kim DK, Park YJ , et al. Areca nut exposure increases secretion of tumor-promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes[J]. Int J Cancer, 2015,137(11):2545-2557.
[30]	Scherz-Shouval R, Elazar Z . Regulation of autophagy by ROS: physiology and pathology[J]. Trends Biochem Sci, 2011,36(1):30-38.
[31]	Ji WT, Yang SR, Chen JY , et al. Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma[J]. Cancer Sci, 2012,103(7):1221-1229.
[32]	Codogno P, Meijer AJ . Autophagy and signaling: their role in cell survival and cell death[J]. Cell Death Differ, 2005,12(Suppl 2):1509-1518.
[33]	Sannigrahi MK, Singh V, Sharma R , et al. Role of autophagy in head and neck cancer and therapeutic resistance[J]. Oral Dis, 2015,21(3):283-291.
[34]	Showkat M, Beigh MA , Andrabi KI. mTOR signaling in protein translation regulation: implications in cancer genesis and therapeutic interventions[J]. Mol Biol Int, 2014,2014:686984.
[35]	Trivedy C, Baldwin D, Warnakulasuriya S , et al. Copper content in areca catechu (betel nut) products and oral submucous fibrosis[J]. Lancet, 1997,349(9063):1447.
[36]	Khan I, Pant I, Narra S , et al. Epithelial atrophy in oral submucous fibrosis is mediated by copper (Ⅱ) and arecoline of areca nut[J]. J Cell Mol Med, 2015,19(10):2397-2412.
[37]	中华口腔医学会口腔黏膜病专业委员会. 口腔黏膜下纤维性变的诊断标准(试行稿)[J]. 中华口腔医学杂志, 2009,44(3):130-131.
	Society of Oral Medicine, Chinese Stomatological Association. Diagnosis criteria of oral submucous fibrosis (draft)[J]. Chin J Stomatol, 2009,44(3):130-131.
[38]	彭解英, 孟庆玉, 李继佳 . 口腔黏膜下纤维性变的诊断研究进展[J]. 中国实用口腔科杂志, 2011,4(2):72-75.
	Peng JY, Meng QY, Li JJ . Diagnosis of oral submucous fibrosis[J]. Chin J PractStomatol, 2011,4(2):72-75.
[39]	Chang MC, Chiang CP, Lin CL , et al. Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit[J]. Oral Oncol, 2005,41(8):757-775.
[40]	Chang LY, Wan HC, Lai YL , et al. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress[J]. Arch Oral Biol, 2013,58(10):1523-1531.
[41]	Chang LY, Wan HC, Lai YL , et al. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells[J]. J Periodontal Res, 2009,44(2):175-183.
[42]	Angadi PV, Rekha KP . Oral submucous fibrosis: a clinicopathologic review of 205 cases in Indians[J]. Oral Maxillofac Surg, 2011,15(1):15-19.
[43]	Chaturvedi P, Vaishampayan SS, Nair S , et al. Oral squamous cell carcinoma arising in background of oral submucous fibrosis: a clinicopathologically distinct disease[J]. Head Neck, 2013,35(10):1404-1409.
[44]	Murgod VV, Kale AD, Angadi PV , et al. Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma[J]. J Oral Sci, 2014,56(2):173-178.
[45]	Murgod VV, Kale AD, Angadi PV , et al. Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma[J]. J Oral Sci, 2014,56(2):173-178.
[46]	Hung TC, Huang LW, Su SJ , et al. Hemeoxygenase-1 expression in response to arecoline-induced oxidative stress in human umbilical vein endothelial cells[J]. Int J Cardiol, 2011,151(2):187-194.
[47]	Ullah M, Cox S, Kelly E , et al. Arecoline is cytotoxic for human endothelial cells[J]. J Oral Pathol Med, 2014,43(10):761-769.
[48]	Qin AP, Liu CF, Qin YY , et al. Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia[J]. Autophagy, 2010,6(6):738-753.
[49]	Janku F, McConkey DJ, Hong DS , et al. Autophagy as a target for anticancer therapy[J]. Nat Rev Clin Oncol, 2011,8(9):528-539.
[50]	O’Donovan TR, O’Sullivan GC, McKenna SL . Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics[J]. Autophagy, 2011,7(5):509-524.
[51]	Lefort S, Joffre C, Kieffer Y , et al. Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers[J]. Autophagy, 2014,10(12):2122-2142.
[52]	Yen CY, Lin MH, Liu SY , et al. Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction[J]. Oral Oncol, 2011,47(5):345-351.
[53]	Chang BE, Liao MH, Kuo MY , et al. Developmental toxicity of arecoline, the major alkaloid in betel nuts, in zebrafish embryos[J]. Birth Defects Res Part A Clin Mol Teratol, 2004,70(1):28-36.
[54]	Xu Z, Huang CM, Shao Z , et al. Autophagy induced by areca nut extract contributes to decreasing cisplatin toxicity in oral squamous cell carcinoma cells: roles of reactive oxygen species/AMPK signaling[J]. Int J Mol Sci, 2017,18(3):524.
[55]	Yeh CY, Chen HM, Chang MC , et al. Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components[J]. J Formos Med Assoc, 2016,115(2):108-112.
[56]	Yen CY, Chiang WF, Liu SY , et al. Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity[J]. J Oral Pathol Med, 2014,43(2):91-96.
[57]	Yen CY, Chiang WF, Liu SY , et al. Impacts of autophagy-inducing ingredient of areca nut on tumor cells[J]. PLoS One, 2015,10(5):e0128011.
[58]	Liu SY, Lin MH, Hsu YR , et al. Arecoline and the 30-100 kDa fraction of areca nut extract differentially regulate mTOR and respectively induce apoptosis and autophagy: a pilot study[J]. J Biomed Sci, 2008,15(6):823-831.
[59]	Sakakura K, Takahashi H, Kaira K , et al. Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma[J]. Cancer Sci, 2015,106(1):1-8.