West China Journal of Stomatology ›› 2019, Vol. 37 ›› Issue (5): 556-562.doi: 10.7518/hxkq.2019.05.020

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Potential application of human microbiomes in the diagnosis and treatment of type 2 diabetes mellitus

Liu Yunkun,Xu Xin,Zhou Xuedong()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-04-15 Revised:2019-07-09 Online:2019-10-01 Published:2019-10-15
  • Contact: Xuedong Zhou E-mail:zhouxd@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(81430011);The National Natural Science Foundation of China(81670978);The Key Project for Frontier Research of Science and Technology Department of Sichuan Province(2016JY0006)

Abstract:

Human microbiome refers to the total microorganism genetic information of human body surface and internal, which is closely related to human health and disease. Oral and gut microbiomes are the most diverse microbial communities, which can interact and play a role in the development of the disease, and can reflect the health and disease state in real time. Type 2 diabetes mellitus is a metabolic disorder caused by both genetic and environmental factors. Recent research has shown a link between microbes and diabetes. This article reviewed the latest research on the changes of oral and gut microbiomes in type 2 diabetes mellitus patients, which expects to provide a reference for exploring the development of the disease model for prediction, diagnosis and prognosis of type 2 diabetes mellitus based on human microbiome characteristics.

Key words: type 2 diabetes mellitus, oral microbiome, gut microbiome, precision medicine

CLC Number: