Effects of platelet-derived growth factor on nerve regeneration around implant in rats

doi:10.7518/hxkq.2019.04.002

Abstract

Abstract:

Objective To investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues. Methods SD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining. Results PDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers. Conclusion PDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.

Key words: platelet-derived growth factor, implant, nerve fiber, nerve regeneration, osseoperception

CLC Number:

R745

Yanying Wang,Ping Gong,Jian Zhang. Effects of platelet-derived growth factor on nerve regeneration around implant in rats[J]. West China Journal of Stomatology, 2019, 37(4): 350-354.

Figures/Tables 4

References 19

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