West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (5): 559-563.doi: 10.7518/hxkq.2018.05.017

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The role of bone morphogenetic protein signaling pathway in tooth root development

Cangwei Liu(),Yijun Zhou,Guangxing Yan,Ce Shi,Xue Zhang,Yue Hu,Xinqing Hao,Huan Zhao,Hongchen Sun()   

  1. Dept. of Oral Pathology, School and Hospital of Stomatology, Jilin University, Key Laboratory of Tooth Development and Bone Remodeling of Jilin Province, Changchun 130021, China
  • Received:2018-04-26 Revised:2018-07-10 Online:2018-10-01 Published:2018-10-18
  • Supported by:
    The National Key Research and Development Special Fund(2016YFC1102800);The National Key Research and Development Special Fund(2016YFC1102804);The National Natural Science Foundation of China(81320108011);The National Natural Science Foundation of China(81600843);The National Natural Science Foundation of China(81600823);The National Natural Science Foundation of China(81600890);Jilin Provincial Health Office Fund(2016Q025);Jilin Provincial Science and Technology Bureau Fund(20150414002GH);Jilin Provincial Science and Technology Bureau Fund(20160312020ZG);Jilin Provincial Science and Technology Bureau Fund(20170520016JH);Jilin Provincial Health and Family Planning Committee Fund(2016C044-3)

Abstract:

The bone morphogenetic protein (BMP) family is an important factor in the regulation of cell ular life activities and in the development of almost all tissues. BMP-mediated signaling plays an important role in tooth root development, which is a part of tooth development. Epithelial and mesenchymal interactions are involved in tooth root development, but the BMP signaling pathway has a different effect on tooth root development in epithelial and mesenchymal. This review summarizes the advances of BMP signaling in tooth root development.

Key words: bone morphogenetic protein, odontogenesis, epithelial root sheath

CLC Number: