West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (2): 204-211.doi: 10.7518/hxkq.2018.02.017

• Orginal Article • Previous Articles     Next Articles

Advances in the molecular mechanisms of perineural invasion in salivary adenoid cystic carcinoma

Mei Zhang1(), Xinhua Liang2, Yaling Tang1()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State Key Labo-ratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-08-05 Revised:2017-12-02 Online:2018-04-10 Published:2018-04-10
  • Supported by:
    Supported by: The National Natural Science Foundation of China (81772891).

Abstract:

Salivary adenoid cystic carcinoma is a very common malignant neoplasm in the salivary glands. One of the most important features of salivary cystic carcinoma is perineural invasion, which renders its complete removal is very difficult through clinical surgery. Consequently, tumor recurrence occurs easily after clinical surgery. Therefore, the molecular mecha-nisms of perineural invasion in salivary adenoid cystic carcinoma are necessary to explore. These mechanisms are reviewed in this paper.

Key words: salivary gland, adenoid cystic carcinoma, perineural invasion, molecular mechanism

CLC Number: