Local injection of exogenous nerve growth factor improves early bone maturation of implants

doi:10.7518/hxkq.2018.02.003

Abstract

Abstract:

Objective To investigate the effects of nerve growth factor (NGF) in the osteogenic action of implants and the maturation and reconstruction changes in bone tissues in the early stage of osseointegration. Methods The mouse implant model was established by placing titanium in the femoral head of the mouse and locally injecting NGF in the implant zone. On 1, 2 and 4 weeks after operation, stain samples were collected from animals using hematoxylin-eosin (HE) staining and Masson staining. The effect of NGF on the bone maturation was compared at different time points of early stage osseointe-gration. Results The results of HE and Masson staining indicated that the local injection of external NGF can up-regulate bone mass, amount of bone trabecula, and bone maturity in the mouse model. The mature bone rate in treatment group of 1 week and 4 weeks after operation were significantly higher than those in the control group (P<0.05). Conclusion NGF can shorten the period of bone maturation.

Key words: nerve growth factor, titanium implant, osseointegration

CLC Number:

R783

Yang Yao, Yu Du, Xia Gu, Mengkai Guang, Bo Huang, Ping. Gong. Local injection of exogenous nerve growth factor improves early bone maturation of implants[J]. West China Journal of Stomatology, 2018, 36(2): 128-132.

Figures/Tables 3

References 24

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