Recent achievements in the microbiological etiology of dental caries

doi:10.7518/hxkq.2018.01.020

Abstract

Abstract:

Dental caries is the most common chronic infectious disease of the oral cavity. The bacterium Streptococcus mutans is the sole pathogen that causes this disease. However, substantial evidence suggests that prevention and treatment strategies developed from traditional “cariogenic pathogen theory” are inefficient in reducing the prevalence of dental caries. An increasing number of individuals adopt the ecological view of the microbiota in the pathogenesis of dental caries. Recent technological improvements have enabled the detection and analysis of oral microorganisms, and many studies have focused on this area. The core microbiota is defined as a cluster of microbes playing critical roles in the initial and development phases of dental caries and may provide future direction for microorganism-related etiological studies.

Key words: dental caries, oral microbiota, etiology, Streptococcus mutans, core microbiota

CLC Number:

R780.2

Jing Chen, Lei Cheng, Xuedong Zhou, Xian. Peng. Recent achievements in the microbiological etiology of dental caries[J]. West China Journal of Stomatology, 2018, 36(1): 104-108.

Figures/Tables 1

References 33

[1]	Vos T, Flaxman AD, Naghavi M, et al.Years lived with disability (YLDs) for 1 160 sequelae of 289 diseases and injuries 1990—2010: a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012, 380(9859):2163-2196.
[2]	齐小秋. 第三次全国口腔健康流行病学调查报告[M]. 北京: 人民卫生出版社, 2008:1-2.
	Qi XQ.The report of the third national oral health epide-miological survey[M]. Beijing: People’s Medical Publishing House, 2008:1-2.
[3]	Takahashi N, Nyvad B.Ecological hypothesis of dentin and root caries[J]. Caries Res, 2016, 50(4):422-431.
[4]	Burne RA, Zeng L, Ahn SJ, et al.Progress dissecting the oral microbiome in caries and health[J]. Adv Dent Res, 2012, 24(2):77-80.
[5]	Marsh PD.Microbial ecology of dental plaque and its sig-nificance in health and disease[J]. Adv Dent Res, 1994, 8(2):263-271.
[6]	周学东. 口腔医学史[M]. 北京: 人民卫生出版社, 2013:213-266.
	Zhou XD.History of stomatology[M]. Beijing: People’s Medical Publishing House, 2013:213-266.
[7]	Lamont RJ, Jenkinson HF.Oral microbiology at a glance[M]. New Jersey: John Wiley & Sons, 2010:89-117.
[8]	Kassebaum NJ, Smith AGC, Bernabé E, et al.Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990—2015: a systematic analysis for the global burden of diseases, in-juries, and risk factors[J]. J Dent Res, 2017, 96(4):380-387.
[9]	Ewoldsen N, Koka S.There are no clearly superior methods for diagnosing, predicting, and noninvasively treating dental caries[J]. J Evid Based Dent Pract, 2010, 10(1):16-17.
[10]	Kleinberg I.A mixed-bacteria ecological approach to under-standing the role of the oral bacteria in dental caries causa-tion: an alternative to Streptococcus mutans and the specific-plaque hypothesis[J]. Crit Rev Oral Biol Med, 2002, 13(2):
	108-125.
[11]	Takahashi N, Nyvad B.Caries ecology revisited: microbial dynamics and the caries process[J]. Caries Res, 2008, 42
	(6):409-418.
[12]	Takahashi N, Nyvad B.The role of bacteria in the caries process: ecological perspectives[J]. J Dent Res, 2011, 90
	(3):294-303.
[13]	Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome[J]. Nature, 2012, 486(7402):207-214.
[14]	Human Microbiome Project Consortium. A framework for human microbiome research[J]. Nature, 2012, 486(7402):215-221.
[15]	石四箴. 儿童口腔医学[M]. 北京: 人民卫生出版社, 2011:112-113.
	Shi SZ.Pediatric stomatology[M]. Beijing: People’s Medi-cal Publishing House, 2011:112-113.
[16]	Jiang W, Jiang Y, Li C, et al.Investigation of supragingival plaque microbiota in different caries status of Chinese pres-chool children by denaturing gradient gel electrophoresis[J]. Microb Ecol, 2011, 61(2):342-352.
[17]	Ma C, Chen F, Zhang Y, et al.Comparison of oral micro-bial profiles between children with severe early childhood caries and caries-free children using the human oral microbe identification microarray[J]. PloS One, 2015, 10(3):e0122075.
[18]	Luo AH, Yang DQ, Xin BC, et al.Microbial profiles in saliva from children with and without caries in mixed dentition[J]. Oral Dis, 2012, 18(6):595-601.
[19]	Jiang W, Zhang J, Chen H.Pyrosequencing analysis of oral microbiota in children with severe early childhood dental caries[J]. Curr Microbiol, 2013, 67(5):537-542.
[20]	Tanner AC, Kent RL, Holgerson PL, et al.Microbiota of severe early childhood caries before and after therapy[J]. J Dent Res, 2011, 90(11):1298-1305.
[21]	Chalmers NI, Oh K, Hughes CV, et al.Pulp and plaque mi-crobiotas of children with severe early childhood caries[J]. J Oral Microbiol, 2015, 7:25951.
[22]	Aas JA, Griffen AL, Dardis SR, et al.Bacteria of dental caries in primary and permanent teeth in children and young adults[J]. J Clin Microbiol, 2008, 46(4):1407-1417.
[23]	Xiao C, Ran S, Huang Z, et al.Bacterial diversity and com-munity structure of supragingival plaques in adults with dental health or caries revealed by 16s pyrosequencing[J]. Front Microbiol, 2016, 7:1145.
[24]	Johansson I, Witkowska E, Kaveh B, et al.The microbiome in populations with a low and high prevalence of caries[J]. J Dent Res, 2016, 95(1):80-86.
[25]	Shay K.Root caries in the older patient: significance, pre-vention, and treatment[J]. Dent Clin North Am, 1997, 41(4):763-793.
[26]	Ravald N.Root surface caries[J]. Curr Opin Periodontol, 1994:78-86.
[27]	Preza D, Olsen I, Aas JA, et al.Bacterial profiles of root caries in elderly patients[J]. J Clin Microbiol, 2008, 46(6):2015-2021.
[28]	Preza D, Olsen I, Willumsen T, et al.Microarray analysis of the microflora of root caries in elderly[J]. Eur J Clin Mi-crobiol Infect Dis, 2009, 28(5):509-517.
[29]	Bizhang M, Ellerbrock B, Preza D, et al.Detection of nine microorganisms from the initial carious root lesions using a TaqMan-based real-time PCR[J]. Oral Dis, 2011, 17(7):642-652.
[30]	Chen L, Qin B, Du M, et al.Extensive description and com-parison of human supra-gingival microbiome in root caries and health[J]. Plos One, 2015, 10(2):e0117064.
[31]	Alaluusua S, Kleemola-Kujala E, Nystrom M, et al.Caries in the primary teeth and salivary Streptococcus mutans and lactobacillus levels as indicators of caries in permanent teeth[J]. Pediatr Dent, 1987, 9(2):126-130.
[32]	Teng F, Yang F, Huang S, et al.Prediction of early child-hood caries via spatial-temporal variations of oral microbiota[J]. Cell Host Microbe, 2015, 18(3):296.
[33]	Yang F, Ning K, Zeng X, et al.Characterization of saliva microbiota’s functional feature based on metagenomic se-quencing[J]. Springerplus, 2016, 5(1):2098.