Expression and clinical significance of proline-rich tyrosine kinase 2 and phospho-protein kinase B in tongue squamous cell carcinoma

doi:10.7518/hxkq.2018.01.006

Abstract

Abstract:

Objective This study aimed to investigate the expression and clinical significance of proline-rich tyrosine kinase 2 (Pyk2) and phospho-protein kinase B (p-AKT) in tongue squamous cell carcinoma (TSCC) and adjacent nontumor tissues. MethodsThe Pyk2 and p-AKT protein levels were detected via immunohistochemistry in 45 cases of TSCC tissues and 30 cases of adjacent nontumor tissues. The relationships of the two protein levels and clinicopathological characteristics were also analyzed. ResultsPyk2 and p-AKT levels were significantly higher in the TSCC tissues than in the adjacent nontumor tissues (P<0.05). Nontumor tissues showed poor or no expression. The expression levels of the two proteins were positively correlated (γ_s=0.412). The expression of Pyk2 was associated with histopathological differentiation type, regional lymph node metastasis, and TNM staging (P<0.05), but not with age and gender. The expression of p-AKT was only related to histopatholo-gical differentiation types (P<0.05). Conclusion The abnormal expression of Pyk2 and p-AKT proteins might be closely related to the development and progression of TSCC. Joint detection can be used as an indicator to estimate the degree of TSCC.

Key words: proline-rich tyrosine kinase 2, phospho-protein kinase B, tongue squamous cell carcinoma

CLC Number:

Lingling Li, Shengzhi Wang, Xuyang Liu, Hao Liu, Zhaohua. Gong. Expression and clinical significance of proline-rich tyrosine kinase 2 and phospho-protein kinase B in tongue squamous cell carcinoma[J]. West China Journal of Stomatology, 2018, 36(1): 29-.

Figures/Tables 4

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Tab 1

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References 9

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组织类型	n	Pyk2				p-AKT
组织类型	n	+	阳性率/%	&#x003c7;²	P值	+	阳性率/%	&#x003c7;²	P值
TSCC组织	45	26	57.78	17.973	0.000	25	55.56	9.780	0.002
癌旁非肿瘤组织	30	2	6.67			5	16.67

临床病理特征		n	Pyk2				p-AKT
临床病理特征		n	+	阳性率/%	&#x003c7;²	P值	+	阳性率/%	&#x003c7;²	P值
性别	男	29	17	58.62	0.024	0.878	18	62.07	1.401	0.236
	女	16	9	56.25			7	43.75
年龄/岁	&#x0003E;60	24	14	58.33	0.007	0.936	13	54.17	0.040	0.841
	&#x02264;60	21	12	57.14			12	57.14
肿瘤直径/cm	&#x02265;3	24	13	54.17	0.275	0.600	14	58.33	0.161	0.688
	&#x0003C;3	21	13	61.90			11	52.38
临床分期	&#x02160;、&#x02161;期	31	13	41.94	8.270	0.004	14	45.16	4.360	0.078
	&#x02162;、&#x02163;期	14	13	92.86			11	78.57
分化程度	高分化	32	15	46.88	3.961	0.047	14	43.75	6.252	0.012
	中、低分化	13	11	84.62			11	84.62
区域淋巴结转移	无	33	15	45.45	5.926	0.015	16	48.48	1.547	0.214
	有	12	11	91.67			9	75.00

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