West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (1): 4-8.doi: 10.7518/hxkq.2018.01.002

• Orginal Article • Previous Articles     Next Articles

Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang

Ruihan Zhang1(), Xiaobing Li2, Liping Wang1, Yishan Liu1()   

  1. 1. Dept. of Pediatric Dentistry & Oral Prevention and Health Care, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Den-tistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-02-28 Revised:2017-11-09 Online:2018-02-07 Published:2018-02-01
  • Supported by:
    Supported by: The National Natural Science Foundation of China (81560178).

Abstract:

Objective This study aims to investigate the association between human leucocyte antigen (HLA)-DQB1 allele polymorphisms and the presence dental caries among the Uygur and Han children in Xinjiang. Methods HLA-DQB1 allele in the Uygur and Han children with dental caries and healthy control in Xinjiang was tested (n=40) using the polymerase chain reaction-sequence specific primer (PCR-SSP) DNA parting technology. Results A total of five specific loci were detected in the HLA-DQB1 locus among the Uygur and Han children. The frequency of the HLA-DQB1*02 allele in the Han group with severe caries (12.5%) was significantly lower than in the control group (32.5%) (P<0.05, OR=0.297). Moreover, the frequency of the HLA-DQB1*05 allele in the Uygur group with severe caries (37.5%) was significantly higher than in the control group (17.5%) (P<0.05, OR=2.829). Conclusion Caries susceptibility among the Uygur and Han children in Xinjiang is related to the HLA-DQB1 allele. The HLA-DQB1*02 allele may protect against caries among the Han children, whereas the HLA-DQB1*05 allele may be responsible for the susceptibility of the Uygur children to caries.

Key words: early childhood caries, human leucocyte antigen, genetic polymorphism

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