Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis

doi:10.7518/hxkq.2017.06.017

Abstract

Abstract:

Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism of P. gingivalis internali-zation and autophagy to illuminate its pathogenesis and to further explore the relationship between P. gingivalis and systemic diseases.

Key words: Porphyromonas gingivalis, autophagy, vascular endothelial cell, gingival epithelial cell

CLC Number:

R781.4

Yan Zhao, Yang Yu, Yurong Kou. Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis[J]. West China Journal of Stomatology, 2017, 35(6): 654-658.

References 33

[1]	Li L, Michel R, Cohen J, et al.Intracellular survival and vascular cell-to-cell transmission of Porphyromonas gin-givalis[J]. BMC Microbiol, 2008, 8:26.
[2]	Levine B, Kroemer G.Autophagy in the pathogenesis of disease[J]. Cell, 2008, 132(1):27-42.
[3]	Takeuchi H, Furuta N, Amano A.Cell entry and exit by periodontal pathogen via recycling pathway[J]. Commun Integr Biol, 2011, 4(5):587-589.
[4]	Zaitsu Y, Iwatake M, Sato K, et al.Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system[J]. Microbes Infect, 2016, 18(9):565-571.
[5]	Park MH, Jeong SY, Na HS, et al.Porphyromonas gingi-valis induces autophagy in THP-1-derived macrophages[J]. Mol Oral Microbiol, 2017, 32(1):48-59.
[6]	Xie H, Cai S, Lamont RJ.Environmental regulation of fim-brial gene expression in Porphyromonas gingivalis[J]. Infect Immun, 1997, 65(6):2265-2271.
[7]	Rodrigues PH, Bélanger M, Dunn W Jr, et al.Porphyromonas gingivalis and the autophagic pathway: an innate immune interaction[J]. Front Biosci, 2008, 13:178-187.
[8]	Yilmaz O, Watanabe K, Lamont RJ.Involvement of inte-grins in fimbriae-mediated binding and invasion by Porphy-romonas gingivalis[J]. Cell Microbiol, 2002, 4(5):305-314.
[9]	Tsuda K, Furuta N, Inaba H, et al.Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles[J]. Cell Struct Funct, 2008, 33(1):123-132.
[10]	da Silva CV, Cruz L, Araújo Nda S, et al. A glance at Lis-teria and Salmonella cell invasion: different strategies to promote host actin polymerization[J]. Int J Med Microbiol, 2012, 302(1):19-32.
[11]	Owen KA, Thomas KS, Bouton AH.The differential ex-pression of Yersinia pseudotuberculosis adhesins determines the requirement for FAK and/or Pyk2 during bacterial pha-gocytosis by macrophages[J]. Cell Microbiol, 2007, 9(3):596-609.
[12]	Rodrigues PH, Reyes L, Chadda AS, et al.Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study[J]. PLoS ONE, 2012, 7(12):e52606.
[13]	邓辉, 吴亚菲, 丁一. 牙龈卟啉单胞菌感染对血管内皮细胞与单核细胞黏附的影响[J]. 实用口腔医学杂志, 2014, 30(5):633-636.
	Deng H, Wu YF, Ding Y.The effects of Porphyromonas gingivalis infection on mononuclear cell adhesion to vas-cular endothelial cells[J]. J Pract Stomatol, 2014, 30(5):633-636.
[14]	Chen T, Nakayama K, Belliveau L, et al.Porphyromonas gingivalis gingipains and adhesion to epithelial cells[J]. In-fect Immun, 2001, 69(5):3048-3056.
[15]	Casadevall A.Evolution of intracellular pathogens[J]. Annu Rev Microbiol, 2008, 62:19-33.
[16]	Yilmaz O, Verbeke P, Lamont RJ, et al.Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells[J]. Infect Immun, 2005, 74(1):703-710.
[17]	Kuma A, Hatano M, Matsui M, et al.The role of autophagy during the early neonatal starvation period[J]. Nature, 2004, 432(7020):1032-1036.
[18]	Kroemer G, Mariño G, Levine B.Autophagy and the inte-grated stress response[J]. Mol Cell, 2010, 40(2):280-293.
[19]	王雅雯, 侯劲松. 自噬基因Beclin 1在肿瘤中的作用及其与口腔癌的关系[J]. 中国实用口腔科杂志, 2011, 4(6):374-376.
	Wang YW, Hou JS.Function of autophagy gene Beclin 1 in tumor and its relationship with oral cancer[J]. Chin J Pract Stomatol, 2011, 4(6):374-376.
[20]	Shintani T, Klionsky DJ.Autophagy in health and disease: a double-edged sword[J]. Science, 2004, 306(5698):990-995.
[21]	Choi AM, Ryter SW, Levine B.Autophagy in human health and disease[J]. N Engl J Med, 2013, 368(7):651-662.
[22]	Levine B, Mizushima N, Virgin HW.Autophagy in immu-nity and inflammation[J]. Nature, 2011, 469(7330):323-335.
[23]	Takeuchi H, Furuta N, Morisaki I, et al.Exit of intracellu-lar Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway[J]. Cell Micro-biol, 2011, 13(5):677-691.
[24]	Amano A, Furuta N, Tsuda K.Host membrane trafficking for conveyance of intracellular oral pathogens[J]. Periodon-tol 2000, 2010, 52(1):84-93.
[25]	Frost LS, Lopes VS, Bragin A, et al.The contribution of melanoregulin to microtubule-associated protein 1 light chain 3 (LC3) associated phagocytosis in retinal pigment epithelium[J]. Mol Neurobiol, 2015, 52(3):1135-1151.
[26]	Blasi I, Korostoff J, Dhingra A, et al.Variants of Porphy-romonas gingivalis lipopolysaccharide alter lipidation of autophagic protein, microtubule-associated protein 1 light chain 3, LC3[J]. Mol Oral Microbiol, 2016, 31(6):486-500.
[27]	Bullon P, Cordero MD, Quiles JL, et al.Autophagy in perio-dontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation[J]. BMC Med, 2012, 10:122.
[28]	Shiheido Y, Maejima Y, Suzuki JI, et al.Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture[J]. J Mol Cell Cardiol, 2016, 99:123-137.
[29]	Dorn BR, Dunn WA Jr, Progulske-Fox A.Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells[J]. Infect Immun, 2001, 69(9):5698-5708.
[30]	Gould GW, Lippincott-Schwartz J.New roles for endosomes: from vesicular carriers to multi-purpose platforms[J]. Nat Rev Mol Cell Biol, 2009, 10(4):287-292.
[31]	Rathinam VA, Vanaja SK, Fitzgerald KA.Regulation of inflammasome signaling[J]. Nat Immunol, 2012, 13(4):333-342.
[32]	Griffiths G.On phagosome individuality and membrane signalling networks[J]. Trends Cell Biol, 2004, 14(7):343-351.
[33]	El-Awady AR, Miles B, Scisci E, et al.Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk[J]. PLoS Pathog, 2015, 10(2):e1004647.