Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis deve-lopment

doi:10.7518/hxkq.2017.04.016

Abstract

Abstract:

Macrophage plays an important role in human innate immune system. It has powerful functions, such as recog-nition, phagocytosis, and bacteria and foreign body removal. Periodontitis, which is a chronic infectious disease characterized by gum inflammation and bone loss, is a major cause of tooth loss in adults. Several studies demonstrated that periodontal tissue destruction is caused by the host immune response defending against infections. As an important part of host immune response, macrophage is also involved in periodontitis pathogenesis. Recently, anti-inflammatory and proresolving activities of macrophage was discovered. Thus, the complex function of macrophage in the occurrence, development, and resolution of inflammation and its potential role in periodontitis were reviewed.

Key words: macrophage, periodontitis, polarization, efferocytosis, proresolving mediators, lipoxin

CLC Number:

R780.2

Lin Bai, Yuejiao Xin, Dingyu Duan, Yi Xu. Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis deve-lopment[J]. West China Journal of Stomatology, 2017, 35(4): 427-432.

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