West China Journal of Stomatology ›› 2017, Vol. 35 ›› Issue (3): 311-316.doi: 10.7518/hxkq.2017.03.015

• Orginal Article • Previous Articles     Next Articles

Clinical significance of CD44 and CD133 expression in oral potentially malignant disorder and oral squamous cell carcinoma

Jiajia Qi1(), Yan Sun1, Changqing Yuan2(), Wenjing Jiang2, Han Zhao3, Yuanpan Cao1, Qiuyan Liu1   

  1. 1. School of Stomatology, Qingdao University, Qingdao 266000, China
    2. Dept. of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China
    3. Dept. of Pathology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China
  • Received:2016-08-11 Revised:2016-12-09 Online:2017-06-05 Published:2017-06-01

Abstract:

Objective This study aims to investigate the expression and relationship of CD44 and CD133 in normal oral mucosa, oral potentially malignant disorder (OPMD), and oral squamous cell carcinoma (OSCC). This work also analyzes the relationship between such expression and clinical factors. This study intends to evaluate the clinical value of using CD44 and CD133 as indices to evaluate the carcinogenic potential of OPMD. Methods Clinical data from 60 patients with OPMD, 60 patients with OSCC, and 10 cases of normal oral mucosa were analyzed. Double immunohistochemical analysis was applied to investigate the expression of CD44 and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues. Subsequently, the relationships between such expression and clinical factors were analyzed. Results The positive rates of CD44 expression in the normal oral mucosa, OPMD, and OSCC tissues were 100.00%, 96.67%, and 71.67% (P<0.05), res-pectively. Meanwhile, the positive rates of CD133 expression in the normal oral mucosa, OPMD, and OSCC tissues were 0.00%, 35.00%, and 63.33% (P<0.05), respectively. The expression of CD44 and CD133 was found to be correlated (P<0.05). Such expression was related to the clinical stages and lymphatic metastasis of OSCC (P<0.05). Conclusion CD44 and CD133 can be used individually as clinical indices to evaluate the carcinogenic potential of OPMD.

Key words: CD44, CD133, oral potentially malignant disorder, oral squamous cell carcinoma, clinical significance

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