West China Journal of Stomatology ›› 2016, Vol. 34 ›› Issue (6): 639-642.doi: 10.7518/hxkq.2016.06.017

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Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth andremodeling

Xu Gaoli, Wu Lili, Wu Zhiwu, Gu Zhiyuan   

  1. School of Stomatology, Zhejiang Chinese Medical University,Hangzhou 310053, China)Supported by: The National Natural Science Foundation of China (81170979); Zhejiang Medical Science and Technology PlanProjects (2015KYB146). Correspondence: Gu Zhiyuan, E-mail: gzy@zju.edu.cn.
  • Received:2015-11-21 Revised:2016-09-13 Online:2016-12-01 Published:2016-12-01

Abstract: The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposedin normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in greatdifficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much aspossible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response tohypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This reviewsummarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilagerepair.

Key words: hypoxia-inducible factor-1α, condylar cartilage, hypoxic, static pressure

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