Abstract:

 Objective To analyze caries activity of nasopharyngeal carcinoma（NPC） patients before and after radiation therapy. The study was also designed to analyze calcium and phosphorus concentrations in saliva of NPC patients before and after radiotherapy. Methods  Twenty-eight NPC patients and 20 healthy controls were included in this study. Resazurin disc method was used to detect caries activity of NPC patients before and after 70 Gy radiotherapy. The atomic absorption spectrometry and molybdenum-stibium antispetrophotography method were used to analyze calcium and phosphorus concentrations in saliva of NPC patients before and after 70 Gy radiotherapy and the healthy controls. Results  The results of resazurin disc method showed caries activity of NPC patients was increased after radiotherapy（P<0.01）. Calcium concentration in saliva of NPC patients before radiotherapy was （63.19±3.27）mg·L-1,
phosphorus concentration was （132.96 ±5.13）mg·L -1. After 70 Gy radiotherapy, calcium concentration was （33.38 ± 0.32）mg·L-1, phosphorus concentration was （49.18±2.66）mg·L-1. The difference of calcium and phosphorus concentrations in saliva before and after radiotherapy was significan（t P<0.01）. Conclusion  Caries activities of NPC patients increase after radiotherapy. Calcium and phosphorus concentrations in saliva decrease after radiation therapy.

Key words: nasopharyngeal carcinoma, radiotherapy, caries activity, saliva, calcium, phosphorus