West China Journal of Stomatology

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Effect of Alendronate sodium on torque-out testing on implant-bone interfaces in estrogen-deficient rabbits with alendronate systemic administration

LI Chun-yan1, ZHOU Yan-min1, WANG Lin1, LI Yan-qiu1, FU Li1, GONG Lin2   

  1. 1. Implant Center, Stomatological Hospital of Jilin University, Changchun 130021, China; 2. Dept. of Stomatology, Central Hospital of China Aerospace Corporation, Beijing 100049, China
  • Received:2011-06-25 Revised:2011-06-25 Online:2011-06-20 Published:2011-06-20
  • Contact: ZHOU Yan-min,Tel:0431-88796025

Abstract:

Objective To investigate the influence of systemic application of Alendronate sodium, a bone resorption inhibitor, on the osseointegration of implant-bone interface in estrogen-deficient rabbits through mechanical assessment. Methods 27 five-month-old Japanese white female rabbits were randomly divided into three groups(9 rabbits each group). An ovariectomy group(OVX), an ovariectomy and Alendronate sodium group(ALN) and a shamed- operated group(S). 12 weeks after operation, implants were installed into bilateral distal femurs and proximal tibias in each group. Alendronate sodium was administrated by intraperitoneal injection in ALN group; meanwhile equivalent of normal saline was administrated by intraperitoneal injection in OVX group and S group. Bone mineral density was measured right after the implant operation and also in 4, 8, 12 weeks. Torque-out values were measured in 4, 8, 12 weeks after animal sacrifice. Results Bone mineral density of tibias in ALN group was closed to S groupand was significantly different from OVX group(P<0.05) after 8 weeks. While after 12 weeks, the bone mineral density of tibias and femurs in ALN group was both closed to S group and was significantly different from OVX group(P<0.05). The torque-out values of tibias in ALN group were closed to S group and were significantly different from OVX group (P<0.05) after 8 weeks. After 12 weeks, the torque-out values of tibias and femurs in ALN group were both closed to S group and were significantly different from OVX group(P<0.05). Conclusion Systemic application of Alendronate sodium in osteoporosis rabbits can improve the bone-implant osseointegration significantly.

Key words: osseointegration, Alendronate sodium, implant, torque-out testing