West China Journal of Stomatology

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Clinicopathologic study on reactive hyperplasia of lymph nodes in maxillofacial regions

LI Zhi-gang1, WANG Xiao1, PAN Xiang-yong1, LI Min2,ZOU Shi-qi1   

  1. 1. Dept. of Stomatology, The Third Hospital of Peking University, Beijing 100191, China; 2. Dept. of Pathology, Basic Medical School, Peking University, Beijing 100191, China
  • Received:2011-04-25 Revised:2011-04-25 Online:2011-04-20 Published:2011-04-20
  • Contact: LI Zhi-gang,Tel: 010-82266333

Abstract:

Objective To investigate the clinicopatholigic features of reactive hyperplasia of lymph nodes in maxillofacial regions. Methods Thirty-two patients with lymph node reactive hyperplasia(LRH) were analyzed clinicopathologically including pathomorphologic manifestation and immunohistochemical expression. Results Histopathology of 32 patients showed significant hyperplasia in folliculus lymphaticus, marginal zone lymph, paracortical area lymph, and seldom mixed hyperplasia. Immunohistochemical study showed that the hyperplastic lymphocytes were mainly composed of CD20 positive B cells positive in 23 cases(72%), CD3 positive T cell in 7 cases(22%), CD20 positive T cell and CD3 positive B cell partially as well as histiocytes in 2 cases(6%). Atypical hyperplasia was found in 10 cases. Conclusion Hyperplastic lymphocytes in LRH of maxillofacial regions are mainly composed of B cells. Malignant transformation may occur in these patients with atypical hyperplasia. Regularity follow up is necessary for these patients.

Key words: lymph node, reactive hyperplasia, maxillofacial region, immunohistochemistry