West China Journal of Stomatology

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Tyrosine kinase A and vascular endothelial growth factor receptor 2 in the invasion and metastasis of salivary adenoid cystic carcinoma

NONG Xiao-lin1, XIA Yong1, YANG Yi-ping2, QING Hai-yun2, LI Jia-quan3, LI Yan-ning4, CAO Yang2, LI Hao1, CHEN Qi1   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Stomatological College, Guangxi Medical University, Nanning 530021, China;2. Dept. of Oral Pathology, Stomatological College, Guangxi Medical University, Nanning 530021, China; 3. Medical Research Center, Guangxi Medical University, Nanning 530021, China;4. Dept. of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China
  • Received:2010-08-25 Revised:2010-08-25 Online:2010-08-20 Published:2010-08-20
  • Contact: NONG Xiao-lin,Tel:0771-5358045

Abstract:

Objective To determine the effect of tyrosine kinase A(TrkA) and vascular endothelial growth factor receptor 2(VEGFR2) in the invasion and metastasis of salivary adenoid cystic carcinoma(SACC).Methods The expression of TrkA and VEGFR2 were detected by immunohistochemical staining in 47 cases of SACC of  salivary glands. Clinical data were reviewed by multivariate prognostic analysis. Results The positive rate of  TrkA and VEGFR2 in SACC was 87.23%(41/47) and 85.11%(40/47) respectively. Express of TrkA and VEGFR2 in  perineural invasion and recurrence group were higher than non-perineural invasion and non-recurrence group.  Significant difference was found in microvessel density(MVD) and VEGFR2 expression within different groups(P<0.05). MVD in perineural invasion group(25.14±2.83) was significantly higher than that in none perineural invasion  group(18.81± 1.33)(P<0.05). MVD in recurrence or metastasis group (26.58±2.38) was significantly higher than that(19.06± 1.39) in none recurrence nor metastasis group(P<0.05). Conclusion Positive correlation between expression of TrkA, VEGFR2 and nerve invasion and vessel metastasis of SACC indicate that TrkA and VEGFR2 play important roles in the invasion and metastasis of SACC. It is possible that TrkA and VEGFR2 could be an aid for evaluating the prognosis of SACC patients.

Key words: tyrosine kinase A, vascular endothelial growth factor receptor 2, salivary adenoid cystic carcinoma, perineural invasion, recurrence, metastasis