骨形态发生蛋白1/tolloid蛋白酶家族在牙及骨组织发育中的作用

doi:10.7518/hxkq.2020.05.020

华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (5): 589-593.doi: 10.7518/hxkq.2020.05.020

骨形态发生蛋白1/tolloid蛋白酶家族在牙及骨组织发育中的作用

谢旭东(), 赵蕾, 吴亚菲, 王骏()

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科,成都 610041

收稿日期:2019-09-22 修回日期:2020-06-15 出版日期:2020-10-01 发布日期:2020-10-14
通讯作者: 王骏 E-mail:1107410744@qq.com;jwang316@sina.com
作者简介:谢旭东,博士,E-mail：1107410744@qq.com
基金资助:
国家自然科学基金(81700980);国家自然科学基金(81771077);四川省科技计划项目(2019YJ0097);中国博士后科学基金(2017M623048);四川大学专职博士后研发基金(2018SCU12018);成都市科技计划项目(2019-YF05-01078-SN)

Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone

Xie Xudong(), Zhao Lei, Wu Yafei, Wang Jun()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2019-09-22 Revised:2020-06-15 Online:2020-10-01 Published:2020-10-14
Contact: Wang Jun E-mail:1107410744@qq.com;jwang316@sina.com
Supported by:
The National Natural Science Foundation of China(81700980);The National Natural Science Foundation of China(81771077);Sichuan Province Science and Technology Support Program(2019YJ0097);China Postdoctoral Science Foundation(2017M623048);Postdoctoral Research Foundation of Sichuan University(2018SCU12018);Chengdu Science and Technology Support Program(2019-YF05-01078-SN)

摘要/Abstract

摘要：

骨形态发生蛋白（BMP）1/tolloid（TLD）蛋白酶家族是一类重要的基质金属蛋白酶,可通过调控细胞外基质的生物合成而在组织、器官生长发育中发挥重要作用。临床报道发现BMP1/TLD蛋白酶家族的编码基因发生突变可导致伴有成骨发育不全的Ⅰ型牙本质发育不全,提示该蛋白酶家族在牙及骨等硬组织发育中具有重要作用。本文将BMP1/TLD蛋白酶家族在牙和骨组织发育中的作用及其机制所取得的研究进展作一综述。

关键词: 骨形态发生蛋白1, 基因敲除, 牙本质发育不全, 成骨发育不全, 细胞外基质

Abstract:

The bone morphogenetic protein (BMP) 1/tolloid (TLD) proteinase family is a group of important metalloproteinases, which play key roles in the growth and development of tissues and organs via regulating the biosynthetic processing of the extracellular matrix. Clinical reports have revealed that mutations in the genes encoding BMP1/TLD proteinases lead to dentinogenesis imperfecta type Ⅰ, accompanied with osteogenesis imperfecta. Therefore, this proteinase family is essential for the development of hard tissues. In this study, we review the research progress in the function and mechanism of the BMP1/TLD proteinase family in the development of teeth and bone.

Key words: bone morphogenetic protein 1, gene knockout, dentinogenesis imperfecta, osteogenesis imperfecta, extracellular matrix

中图分类号:

谢旭东, 赵蕾, 吴亚菲, 王骏. 骨形态发生蛋白1/tolloid蛋白酶家族在牙及骨组织发育中的作用[J]. 华西口腔医学杂志, 2020, 38(5): 589-593.

Xie Xudong, Zhao Lei, Wu Yafei, Wang Jun. Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone[J]. West China Journal of Stomatology, 2020, 38(5): 589-593.

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骨形态发生蛋白1/tolloid蛋白酶家族在牙及骨组织发育中的作用

Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone

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