华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (4): 425-430.doi: 10.7518/hxkq.2020.04.013

• 综述 • 上一篇    下一篇

环状RNA与口腔鳞状细胞癌研究进展

雷可昕1(), 白贺天1, 杨淞月2, 李敬1(), 陈谦明1   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院,成都 610041
    2.四川大学华西临床医学院,成都 610041
  • 收稿日期:2018-10-18 修回日期:2020-05-19 出版日期:2020-08-01 发布日期:2020-08-03
  • 通讯作者: 李敬 E-mail:lijing1984@scu.edu.com
  • 作者简介:雷可昕,学士,E-mail: vegecuteone@163.com
  • 基金资助:
    国家自然科学基金(81872211);国家自然科学基金(81672675);国家自然科学基金(81621062);高等学校学科创新引智计划(B14038);中国科协青年人才托举工程(2017QNRC001);四川大学大学生创新实验项目(20171083)

Research progress on circular RNA in oral squamous cell carcinoma

Lei Kexin1(), Bai Hetian1, Yang Songyue2, Li Jing1(), Chen Qianming1   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. West China Clinical Medicine School, Sichuan University, Chengdu 610041, China
  • Received:2018-10-18 Revised:2020-05-19 Online:2020-08-01 Published:2020-08-03
  • Contact: Li Jing E-mail:lijing1984@scu.edu.com
  • Supported by:
    The National Natural Science Foundation of China(81872211);The National Natural Science Foundation of China(81672675);The National Natural Science Foundation of China(81621062);Discipline Innovation and Wisdom Introduction Program for Institutions of High Learning(B14038);The Young Elite Scientist Sponsorship Program by China Association for Science and Technology(2017QNRC001);The Sichuan University Innovation and Entrepreneurship Training Program for Undergraduates(20171083)

摘要:

环状RNA(circRNA)是一种在真核生物中广泛存在的闭合环状非编码RNA,其生成机制、生物学功能的研究进展显示环状RNA可能在包括肿瘤、神经系统疾病、心血管疾病的发生发展过程中扮演重要角色,具有作为疾病标志物的潜能。口腔鳞状细胞癌(OSCC)是口腔外科最常见的恶性肿瘤之一,具有难治疗、易转移、预后差等的特点,由于其发生机制尚不明确,从基因层面阻断OSCC尚不能实现。而环状RNA在OSCC领域的研究进展将为OSCC的生物治疗带来新的思路。本文归纳综述了环状RNA的成环机制、生物学功能及在肿瘤尤其是OSCC发展中的研究进展。

关键词: 环状RNA, 成环机制, 生物学功能, 口腔鳞状细胞癌, 生物标记物

Abstract:

Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.

Key words: circular RNA, biogenesis of circRNA, biology function, oral squamous cell carcinoma, biomarker

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