炎症性牙根外吸收致病机制的研究进展

doi:10.7518/hxkq.2019.06.015

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (6): 656-659.doi: 10.7518/hxkq.2019.06.015

炎症性牙根外吸收致病机制的研究进展

吴佳益,李鑫,汪成林,叶玲,杨静

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓科,成都 610041

收稿日期:2019-03-12 修回日期:2019-06-19 出版日期:2019-12-01 发布日期:2019-11-27
作者简介:吴佳益,学士,E-mail：819304495@qq.com
基金资助:
国家自然科学基金青年基金(81600859);四川省科技厅科技创新苗子工程项目([17-YCG053(2017036)])

Research progress on the pathogenesis of inflammatory external root resorption

Wu Jiayi,Li Xin,Wang Chenglin,Ye Ling,Yang Jing

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2019-03-12 Revised:2019-06-19 Online:2019-12-01 Published:2019-11-27
Supported by:
The National Natural Science Foundation of China(81600859);Sci-tech Innovation Seedling Project of Science and Technology Department of Sichuan Province([17-YCG053(2017036)])

摘要/Abstract

摘要：

炎症性牙根外吸收是指在感染、压力、创伤及正畸治疗等多种物理化学因素刺激下人体自身免疫系统溶解牙根外表面硬组织的病理性过程。严重的炎症性牙根外吸收可导致牙体牙髓、牙周疾病,甚至牙缺失。因此,了解其致病机制对预防及治疗炎症性牙根外吸收有重要意义。本文对炎症性牙根外吸收的致病机制进行综述。

关键词: 炎症性牙根外吸收, 牙骨质, 致病机制

Abstract:

Inflammatory external root resorption (IERR) refers to the pathological process of dissolving the hard tissue on the outer surface of the tooth root by the body’s own immune system under the stimulation of various physical and chemical factors such as infection, stress, trauma and orthodontic treatment. Severe IERR can lead to endodontic and periodontal diseases, and even the loss of teeth. Therefore, understanding the etiology and the pathogenic mechanism of IERR are of importance in its prevention and treatment. This article will review the etiology and the regulation mechanisms of IERR.

Key words: inflammatory external root resorption, cementum, pathogenesis

中图分类号:

R781

吴佳益,李鑫,汪成林,叶玲,杨静. 炎症性牙根外吸收致病机制的研究进展[J]. 华西口腔医学杂志, 2019, 37(6): 656-659.

Wu Jiayi,Li Xin,Wang Chenglin,Ye Ling,Yang Jing. Research progress on the pathogenesis of inflammatory external root resorption[J]. West China Journal of Stomatology, 2019, 37(6): 656-659.

参考文献 27

[1]	Fuss Z, Tsesis I, Lin S . Root resorption—diagnosis, classification and treatment choices based on stimulation factors[J]. Dent Traumatol, 2003,19(4):175-182. doi: 10.1034/j.1600-9657.2003.00192.x URL pmid: 12848710
[2]	Tronstad L . Root resorption-etiology, terminology and clinical manifestations[J]. Dent Traumatol, 1988,4(6):241-252. doi: 10.1111/j.1600-9657.1988.tb00642.x URL pmid: 3078294
[3]	Zhao N, Nociti FH Jr, Duan PP , et al. Isolation and functional analysis of an immortalized murine cementocyte cell line, IDG-CM6[J]. J Bone Miner Res, 2016,31(2):430-442. doi: 10.1002/jbmr.2690 URL pmid: 26274352
[4]	Lim WH, Liu B, Hunter DJ , et al. Downregulation of Wnt causes root resorption[J]. Am J Orthod Dentofacial Orthop, 2014,146(3):337-345. doi: 10.1016/j.ajodo.2014.05.027 URL pmid: 25172256
[5]	Hatakeyama J, Sreenath T, Hatakeyama Y , et al. The receptor activator of nuclear factor-κb ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice[J]. J Biol Chem, 2003,278(37):35743-35748. doi: 10.1074/jbc.M306284200 URL pmid: 12851394
[6]	Zheng Y, Chen M, He L , et al. Mesenchymal dental pulp cells attenuate dentin resorption in homeostasis[J]. J Dent Res, 2015,94(6):821-827. doi: 10.1177/0022034515575347 URL pmid: 25762594
[7]	Rumpler M, Würger T, Roschger P , et al. Osteoclasts on bone and dentin in vitro: mechanism of trail formation and comparison of resorption behavior[J]. Calcif Tissue Int, 2013,93(6):526-539. doi: 10.1007/s00223-013-9786-7 URL pmid: 24022329
[8]	Geblinger D, Addadi L, Geiger B . Nano-topography sensing by osteoclasts[J]. J Cell Sci, 2010,123(9):1503-1510. doi: 10.1242/jcs.060954 URL pmid: 20375065
[9]	Segeletz S, Hoflack B . Proteomic approaches to study osteoclast biology[J]. Proteomics, 2016,16(19):2545-2556. doi: 10.1002/pmic.201500519 URL pmid: 27350065
[10]	Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ , et al. Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs[J]. J Bone Miner Res, 2016,31(7):1356-1365. doi: 10.1002/jbmr.2807 URL pmid: 26852281
[11]	Abbott P . Prevention and management of external inflammatory resorption following trauma to teeth[J]. Aust Dent J, 2016,61:82-94. doi: 10.1111/adj.12400 URL pmid: 26923450
[12]	Albuquerque MP, Junqueira J, Coelho MP , et al. Novel in vitro methodology for induction of Enterococcus faecalis biofilm on apical resorption areas[J]. Indian J Dent Res, 2014,25(4):535-538. doi: 10.4103/0970-9290.142569 URL pmid: 25307923
[13]	Zhao N, Foster BL, Bonewald LF . The cementocyte—an osteocyte relative[J]. J Dent Res, 2016,95(7):734-741. doi: 10.1177/0022034516641898 URL pmid: 27029548
[14]	Li YY, Hu ZA, Zhou CC , et al. Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts[J]. BMC Cell Biol, 2017,18(1):1-12. doi: 10.1186/s12860-016-0124-6 URL pmid: 28068896
[15]	Murata N, Ioi H, Ouchi M , et al. Effect of allergen sensitization on external root resorption[J]. J Dent Res, 2013,92(7):641-647. doi: 10.1177/0022034513488787 URL
[16]	Georgess D, Machuca-Gayet I, Blangy A , et al. Podosome organization drives osteoclast-mediated bone resorption[J]. Cell Adh Migr, 2014,8(3):192-204. doi: 10.4161/cam.27840 URL pmid: 24714644
[17]	Kikuta J, Yamaguchi M, Shimizu M , et al. Notch signaling induces root resorption via RANKL and IL-6 from hPDL cells[J]. Orthod Wav, 2015,94(1):140-147. doi: 10.1177/0022034514555364 URL pmid: 25376720
[18]	Novak ML, Koh TJ . Phenotypic transitions of macrophages orchestrate tissue repair[J]. Am J Pathol, 2013,183(5):1352-1363. doi: 10.1016/j.ajpath.2013.06.034 URL pmid: 24091222
[19]	He D, Kou X, Luo Q , et al. Enhanced M1/M2 macrophage ratio promotes orthodontic root resorption[J]. J Dent Res, 2015,94(1):129-139. doi: 10.1177/0022034514553817 URL pmid: 25344334
[20]	Davies LC, Jenkins SJ, Allen JE , et al. Tissue-resident macrophages[J]. Nat Immunol, 2013,14(10):986-995. doi: 10.1038/ni.2705 URL
[21]	Hunter MM, Wang A, Parhar KS , et al. In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice[J]. Gastroenterology, 2010,138(4):1395-1405. doi: 10.1053/j.gastro.2009.12.041 URL pmid: 20044996
[22]	Lu X, Ito Y, Atsawasuwan P , et al. Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway[J]. Bone, 2013,54(1):157-168. doi: 10.1016/j.bone.2013.01.041 URL
[23]	Sriarj W, Aoki K, Ohya K , et al. Bovine dentine organic matrix down-regulates osteoclast activity[J]. J Bone Miner Metabol, 2009,27(3):315-323. doi: 10.1007/s00774-009-0063-9 URL pmid: 19296049
[24]	Duong LT, Lakkakorpi PT, Nakamura I , et al. PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v) beta3 integrin, and phosphorylated by src kinase[J]. J Clin Invest, 1998,102(5):881-892. doi: 10.1172/JCI3212 URL pmid: 9727056
[25]	Shyu JF, Shih C, Tseng CY , et al. Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities[J]. Bone, 2007,40(5):1329-1342. doi: 10.1016/j.bone.2007.01.014 URL
[26]	Matsumoto N, Daido S, Sun-Wada GH , et al. Diversity of proton pumps in osteoclasts: V-ATPase with a3 and d2 isoforms is a major form in osteoclasts[J]. Biochim Biophys Acta, 2014,1837(6):744-749. doi: 10.1016/j.bbabio.2014.02.011 URL pmid: 24561225
[27]	Teitelbaum SL . Osteoclasts: what do they do and how do they do it[J]. Am J Pathol, 2007,170(2):427-435. doi: 10.2353/ajpath.2007.060834 URL pmid: 17255310

炎症性牙根外吸收致病机制的研究进展

Research progress on the pathogenesis of inflammatory external root resorption

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 27

相关文章 14

编辑推荐

Metrics

本文评价

[1]	韩岳, 刘逸轩, 赵吉宏, 钟皓研. 牙骨质-骨化纤维瘤切除术同期联合异位尖牙自体牙移植1例[J]. 华西口腔医学杂志, 2023, 41(6): 731-736.
[2]	邬浩, 李莹, 王玉琢, 于继泽, 包幸福, 胡敏. 重组人成纤维细胞生长因子21调节成牙骨质细胞矿化作用及其机制研究[J]. 华西口腔医学杂志, 2023, 41(2): 140-148.
[3]	黄能文, 邱灵, 李一, 李龙江. 颊部黏膜下的牙骨质-骨化纤维瘤1例[J]. 华西口腔医学杂志, 2023, 41(1): 110-113.
[4]	王春萌,洪丽华,张志民,王渝. 牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用及机制[J]. 华西口腔医学杂志, 2019, 37(5): 521-526.
[5]	柏思羽,陈悦,戴红卫,黄兰. 机械压应力下骨硬化蛋白对成牙骨质细胞功能影响及机制的体外研究[J]. 华西口腔医学杂志, 2019, 37(2): 162-167.
[6]	王虎. 牙骨质结构不良的X线多样性表现与口腔临床相关性[J]. 华西口腔医学杂志, 2017, 35(6): 565-570.
[7]	陈悦,李书琴,黄兰,戴红卫. 骨形态发生蛋白2对成牙骨质细胞中硬化蛋白表达调控机理的研究[J]. 华西口腔医学杂志, 2016, 34(3): 244-247.
[8]	许来青刘媛媛罗晶晶姜曚郭文豪郑广宁. 成牙骨质细胞瘤的临床及影像表现分析[J]. 华西口腔医学杂志, 2015, 33(4): 419-422.
[9]	李书琴杨珊任嫒姝戴红卫. 张应力刺激下Wnt/β-catenin信号通路对成牙骨质细胞Runx2表达调控的体外研究[J]. 华西口腔医学杂志, 2015, 33(1): 35-39.
[10]	方冬1 江寰2 林志勇2. 锥形束CT用于评价离体牙槽骨高度准确性的研究[J]. 华西口腔医学杂志, 2012, 30(6): 603-606.
[11]	陆润梁文武杨湛刘春海赵悦涛 . 巨大型牙骨质-骨化纤维瘤1例[J]. 华西口腔医学杂志, 2010, 28(06): 682-683.
[12]	隋文,洪咏龙,肖明振. 牙骨质基质提取物促进牙周细胞在牙根表面附着的研究[J]. , 1999, 17(02): 0-.
[13]	翦新春,王承兴,王树芝. 糖尿病患者牙周炎患牙牙小皮形态特征的初步观察[J]. , 1999, 17(01): 0-.
[14]	吴其勤，李树斌，朱忠信. 下颌骨牙骨质化纤维瘤一例[J]. , 1994, 12(04): 0-.