血小板衍生生长因子对大鼠种植体周围神经再生影响的研究

doi:10.7518/hxkq.2019.04.002

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (4): 350-354.doi: 10.7518/hxkq.2019.04.002

血小板衍生生长因子对大鼠种植体周围神经再生影响的研究

王艳颖¹,宫苹²,张健¹()

1.天津市口腔医院（南开大学附属口腔医院）种植科,天津 300041
2.口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院种植科,成都 610041

收稿日期:2018-08-20 修回日期:2019-05-09 出版日期:2019-08-01 发布日期:2019-08-23
通讯作者: 张健 E-mail:zhangstoma@hotmail.com
作者简介:王艳颖,主治医师,博士,E-mail：24548356@qq.com
基金资助:
国家自然科学基金面上项目(81571008);天津市口腔医院博硕士重点课题项目(2015BSZD08);生物活性材料教育部重点实验室（南开大学）开放基金(2018003)

Effects of platelet-derived growth factor on nerve regeneration around implant in rats

Yanying Wang¹,Ping Gong²,Jian Zhang¹()

1.Dept. of Implantology, Tianjin Stomatological Hospital; Hospital of Stomatology, Nankai University, Tianjin 300041, China
2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2018-08-20 Revised:2019-05-09 Online:2019-08-01 Published:2019-08-23
Contact: Jian Zhang E-mail:zhangstoma@hotmail.com
Supported by:
The National Natural Science Foundation of China(81571008);Key Project of Master's Degree in Tianjin Stomatological Hospital(2015BSZD08);Open Fund of Key Laboratory of Bioactive Material for Ministry of Education, Nankai University(2018003)

摘要/Abstract

摘要：

目的探讨血小板衍生生长因子（PDGF）对大鼠种植体周围神经再生的影响。方法建立大鼠股骨植入种植体模型,愈合早期连续注射PDGF,采用免疫组化染色的方法分析PDGF对种植体周围神经再生的影响。结果 PDGF增加大鼠股骨种植体周围早期神经纤维数量,对种植体周围后期神经纤维数量无显著影响。同时,这些神经具有周围神经纤维的典型结构。结论 PDGF可以促进种植体周围早期神经再生。本研究为实现PDGF促进种植体周围神经再生,进而改善种植体感觉功能的临床应用,提供一定的实验依据。

关键词: 血小板衍生生长因子, 种植体, 神经纤维, 神经再生, 骨感知

Abstract:

Objective To investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues. Methods SD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining. Results PDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers. Conclusion PDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.

Key words: platelet-derived growth factor, implant, nerve fiber, nerve regeneration, osseoperception

中图分类号:

R745

王艳颖,宫苹,张健. 血小板衍生生长因子对大鼠种植体周围神经再生影响的研究[J]. 华西口腔医学杂志, 2019, 37(4): 350-354.

Yanying Wang,Ping Gong,Jian Zhang. Effects of platelet-derived growth factor on nerve regeneration around implant in rats[J]. West China Journal of Stomatology, 2019, 37(4): 350-354.

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血小板衍生生长因子对大鼠种植体周围神经再生影响的研究

Effects of platelet-derived growth factor on nerve regeneration around implant in rats

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