华西口腔医学杂志 ›› 2018, Vol. 36 ›› Issue (5): 559-563.doi: 10.7518/hxkq.2018.05.017

• 综述 • 上一篇    下一篇

骨形态发生蛋白信号通路在牙根发育中的作用

刘苍维(),周怡君,闫广兴,史册,张雪,胡月,郝新青,赵欢,孙宏晨()   

  1. 吉林大学口腔医院病理科,吉林省牙发育及颌骨重塑与再生重点实验室,长春 130021
  • 收稿日期:2018-04-26 修回日期:2018-07-10 出版日期:2018-10-01 发布日期:2018-10-18
  • 作者简介:刘苍维,硕士,E-mail: 906808651@qq.com
  • 基金资助:
    国家重点研发专项基金(2016YFC1102800);国家重点研发专项基金(2016YFC1102804);国家自然科学基金(81320108011);国家自然科学基金(81600843);国家自然科学基金(81600823);国家自然科学基金(81600890);吉林省卫生厅基金(2016Q025);吉林省科技厅基金(20150414002GH);吉林省科技厅基金(20160312020ZG);吉林省科技厅基金(20170520016JH);吉林省卫生和计划生育委员会基金(2016C044-3)

The role of bone morphogenetic protein signaling pathway in tooth root development

Cangwei Liu(),Yijun Zhou,Guangxing Yan,Ce Shi,Xue Zhang,Yue Hu,Xinqing Hao,Huan Zhao,Hongchen Sun()   

  1. Dept. of Oral Pathology, School and Hospital of Stomatology, Jilin University, Key Laboratory of Tooth Development and Bone Remodeling of Jilin Province, Changchun 130021, China
  • Received:2018-04-26 Revised:2018-07-10 Online:2018-10-01 Published:2018-10-18
  • Supported by:
    The National Key Research and Development Special Fund(2016YFC1102800);The National Key Research and Development Special Fund(2016YFC1102804);The National Natural Science Foundation of China(81320108011);The National Natural Science Foundation of China(81600843);The National Natural Science Foundation of China(81600823);The National Natural Science Foundation of China(81600890);Jilin Provincial Health Office Fund(2016Q025);Jilin Provincial Science and Technology Bureau Fund(20150414002GH);Jilin Provincial Science and Technology Bureau Fund(20160312020ZG);Jilin Provincial Science and Technology Bureau Fund(20170520016JH);Jilin Provincial Health and Family Planning Committee Fund(2016C044-3)

摘要:

骨形态发生蛋白(BMP)家族是调节细胞生命活动的重要因子,几乎参与了所有组织的发育。BMP介导的信号通路在牙发育过程中发挥十分重要的作用,而牙根发育是牙发育的一部分,是上皮和间充质相互作用的复杂过程。上皮和牙胚间充质中的BMP信号通路在牙根发育中的作用也有所不同,本文综述了BMP信号通路在牙根发育中作用的研究进展。

关键词: 骨形态发生蛋白, 牙发生, 上皮根鞘

Abstract:

The bone morphogenetic protein (BMP) family is an important factor in the regulation of cell ular life activities and in the development of almost all tissues. BMP-mediated signaling plays an important role in tooth root development, which is a part of tooth development. Epithelial and mesenchymal interactions are involved in tooth root development, but the BMP signaling pathway has a different effect on tooth root development in epithelial and mesenchymal. This review summarizes the advances of BMP signaling in tooth root development.

Key words: bone morphogenetic protein, odontogenesis, epithelial root sheath

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