华西口腔医学杂志 ›› 2018, Vol. 36 ›› Issue (4): 441-446.doi: 10.7518/hxkq.2018.04.016

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壳聚糖复合材料在骨组织工程中的研究进展

丁鑫鑫1(), 周延民1(), 相星辰1, 孟琳2, 秦勤1, 叶珊1   

  1. 1.吉林大学口腔医院种植中心
    2.病理科,长春 130021
  • 收稿日期:2017-06-30 修回日期:2018-05-16 出版日期:2018-08-01 发布日期:2018-08-01
  • 作者简介:

    丁鑫鑫,硕士,E-mail:1908018918@qq.com

  • 基金资助:
    国家自然科学基金(81570983);高技术产业发展基金(2014G075)

Research progress on chitosan composite scaffolds in bone tissue engineering

Xinxin Ding1(), Yanmin Zhou1(), Xing-chen Xiang1, Lin Meng2, Qin Qin1, Shan Ye1   

  1. 1. Dept. of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
    2. Dept. of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2017-06-30 Revised:2018-05-16 Online:2018-08-01 Published:2018-08-01
  • Supported by:
    The National Natural Science Foundation of China (81570983);High Technology Industrial Development (2014G075)

摘要:

骨组织工程是利用生物学和工程学方法研制能修复或替代人类骨组织材料的科学领域。支架是组织工程的关键要素,为细胞和组织生长提供结构支持和黏附位点。支架可以由金属、聚合物和陶瓷生物材料制成,其中聚合物支架由于其生物相容性、生物可降解性和机械稳定性而被广泛应用。而壳聚糖(CS)作为甲壳素衍生的天然聚合物,过去20年在骨组织工程中发挥了重要作用。近年来,CS复合材料在骨组织工程领域的应用受到相当大的关注,因为它具有更小的异物反应,优良的抗菌性、可塑性,适合细胞向内生长和骨传导。本文将讨论常见的几种CS复合材料在骨组织工程中的生物相容性及体内外促成骨研究。

关键词: 骨组织工程, 壳聚糖, 支架材料, 骨再生, 成骨细胞

Abstract:

Bone tissue engineering is a scientific field devoted to the development of materials that can repair or replace human bone tissue with biological and engineering methods. The stent, which provides structural support and adhesion sites for cell and tissue growth, is one of the key elements in tissue engineering. The scaffold may comprise metal, polymer, and ceramic biomaterial. The polymer scaffold is widely used due to its biocompatibility, biodegradability, and mechanical stability. Chitosan, as a natural polymer, is derived from chitin and has played a particularly important role in bone tissue engineering over the past two decades. In recent years, chitosan composites and their application in bone tissue engineering have received considerable attention due to their small foreign body reaction, excellent antibacterial properties, plasticity, suitability for inward cell growth, and bone conduction. This review will discuss the biocompatibility and osteogenesis research in vivo and in vitro of several common chitosan composites in bone tissue engineering.

Key words: bone tissue engineering, chitosan, scaffold, bone regeneration, osteoblast

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