华西口腔医学杂志 ›› 2017, Vol. 35 ›› Issue (6): 654-658.doi: 10.7518/hxkq.2017.06.017

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牙龈卟啉单胞菌调控细胞自噬的分子机制研究进展

赵妍1(), 于阳2, 寇育荣1,2()   

  1. 1.中国医科大学附属口腔医院牙周科
    2.口腔生物学教研室,沈阳 110002
  • 收稿日期:2017-02-14 修回日期:2017-05-12 出版日期:2017-12-20 发布日期:2017-12-01
  • 作者简介:

    赵妍,硕士,E-mail:zzyan0802@hotmail.com

  • 基金资助:
    国家自然科学基金(81300886)

Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis

Yan Zhao1(), Yang Yu2, Yurong Kou1,2()   

  1. 1. Dept. of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, China
    2. Dept. of Oral Biology, School of Stomatology, China Medical University, Shenyang 110002, China
  • Received:2017-02-14 Revised:2017-05-12 Online:2017-12-20 Published:2017-12-01
  • Supported by:
    Supported by: The National Natural Science Foundation of China (81300886).

摘要:

细胞自噬是细胞内一种保守的降解代谢途径,是宿主防御细菌感染的关键步骤。牙龈卟啉单胞菌(P. gin-givalis)作为一种牙周致病菌,能够利用其引发的细胞自噬实现其在宿主细胞内的生存和增殖,从而逃避宿主的免疫监视。本文就P. gingivalis内化并调控各种宿主细胞发生自噬的分子机制作一综述,从而深入探讨P. gingivalis的致病作用,并拓展P. gingivalis与全身疾病关系的研究思路。

关键词: 牙龈卟啉单胞菌, 细胞自噬, 血管内皮细胞, 牙龈上皮细胞

Abstract:

Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism of P. gingivalis internali-zation and autophagy to illuminate its pathogenesis and to further explore the relationship between P. gingivalis and systemic diseases.

Key words: Porphyromonas gingivalis, autophagy, vascular endothelial cell, gingival epithelial cell

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